PMID- 22720191
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2042-0080 (Electronic)
IS  - 2090-8083 (Print)
IS  - 2042-0080 (Linking)
VI  - 2012
DP  - 2012
TI  - An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the 
      Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of 
      Presymptomatic Parkinson's Disease.
PG  - 129605
LID - 10.1155/2012/129605 [doi]
LID - 129605
AB  - Compensatory changes occurring during presymptomatic stages of Parkinson's 
      disease (PD) would explain that the clinical symptoms of the disease appear late, 
      when the degenerative process is quite advanced. Several data support the 
      proposition that brain-derived neurotrophic factor (BDNF) could play a role in 
      these plastic changes. In the present study, we evaluated the expression of the 
      specific BDNF receptor, trkB, in a rat model of presymptomatic PD generated by 
      intrastriatal injection of the neurotoxin 6-OHDA. Immunohistochemical studies 
      revealed a decrease in trkB expression in SN pars compacta (SNc) seven days after 
      6-OHDA injection. At this time point, no change in the number of tyrosine 
      hydroxylase (TH) immunoreactive (TH-IR) cells is detected, although a decrease is 
      evident 14 days after neurotoxin injection. The decrease in TH-positive cells and 
      trkB expression in SNc was significantly prevented by systemic administration of 
      Ifenprodil, a specific antagonist of NR2B-containing NMDA receptors. Therefore, 
      an NR2B-NMDA receptor-dependent decrease in trkB expression precedes the 
      disappearance of TH-IR cells in SNc in response to 6-OHDA injection. These 
      results support the idea that a functional coupling between NMDA receptors and 
      BDNF/trkB signalling may be important for the maintenance of the dopaminergic 
      phenotype in SNc during presymptomatic stages of PD.
FAU - Riquelme, Eduardo
AU  - Riquelme E
AD  - Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, 
      Pontificia Universidad Catolica de Chile, Alameda 340, 8331150 Santiago, Chile.
FAU - Abarca, Jorge
AU  - Abarca J
FAU - Campusano, Jorge M
AU  - Campusano JM
FAU - Bustos, Gonzalo
AU  - Bustos G
LA  - eng
PT  - Journal Article
DEP - 20120607
PL  - United States
TA  - Parkinsons Dis
JT  - Parkinson's disease
JID - 101539877
PMC - PMC3377358
EDAT- 2012/06/22 06:00
MHDA- 2012/06/22 06:01
PMCR- 2012/06/07
CRDT- 2012/06/22 06:00
PHST- 2012/01/10 00:00 [received]
PHST- 2012/03/19 00:00 [revised]
PHST- 2012/04/02 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/06/22 06:01 [medline]
PHST- 2012/06/07 00:00 [pmc-release]
AID - 10.1155/2012/129605 [doi]
PST - ppublish
SO  - Parkinsons Dis. 2012;2012:129605. doi: 10.1155/2012/129605. Epub 2012 Jun 7.