PMID- 2272135
OWN - NLM
STAT- MEDLINE
DCOM- 19910222
LR  - 20190510
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 13
IP  - 11
DP  - 1990 Nov
TI  - Acute anterior myocardial infarction: streptokinase prevents ventricular 
      thrombosis independently of its effect on infarct size.
PG  - 789-93
AB  - Left ventricular thrombosis (LVT) is a frequent complication after acute anterior 
      myocardial infarction (AMI). The purpose of this study is to evaluate whether 
      streptokinase (SK) therapy prevents LVT, and whether this effect is due to the 
      preservation of left ventricular function or to the fibrinolytic action of the 
      drug. Sixty-five patients who underwent a left ventricular angiography within 2 
      months after a first AMI were studied. Twenty-eight patients (SK group) received 
      SK 1,500,000 U i.v. administered over 60 min within 6 h from the onset of 
      symptoms. A lower incidence of LVT was found in the SK group (p = 0.0003). We 
      divided patients into two classes according to the value of akinetic-dyskinetic 
      area (AD): the first group with a lower value of AD, the second group with a 
      higher value of AD. In both groups, a reduced incidence of LVT was associated 
      with SK therapy (p = 0.014, p = 0.015, respectively). Early infusion of SK during 
      AMI seems to prevent the development of LVT, with an effect partly independent 
      from its action on infarct size for small to large myocardial infarction.
FAU - Destro, G
AU  - Destro G
AD  - Division of Cardiology, University of Verona, Italy.
FAU - Barbieri, E
AU  - Barbieri E
FAU - Bicego, D
AU  - Bicego D
FAU - Zanolla, L
AU  - Zanolla L
FAU - Franceschini, L
AU  - Franceschini L
FAU - Zardini, P
AU  - Zardini P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - Female
MH  - Fibrinolysis/drug effects
MH  - Heart Diseases/etiology/*prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*drug therapy
MH  - Streptokinase/pharmacology/*therapeutic use
MH  - Thrombosis/etiology/*prevention & control
MH  - Ventricular Function, Left/drug effects
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
AID - 10.1002/clc.4960131108 [doi]
PST - ppublish
SO  - Clin Cardiol. 1990 Nov;13(11):789-93. doi: 10.1002/clc.4960131108.