PMID- 22721716
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20151119
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 13
IP  - 7
DP  - 2012 Aug
TI  - Respiratory response to proton pump inhibitor treatment in children with 
      obstructive sleep apnea syndrome and gastroesophageal reflux disease.
PG  - 824-30
LID - 10.1016/j.sleep.2012.04.016 [doi]
AB  - OBJECTIVE: Evaluation of the respiratory response to proton pump inhibitors (PPI) 
      in children with obstructive sleep apnea syndrome (OSAS) and gastroesophageal 
      reflux disease (GERD). METHODS: Of 131 children diagnosed with OSAS (Apnea 
      Hypopnea Index, AHI >1/h), 37 children (6.9 years; 28.24%) with GERD symptoms (>3 
      times/week) were included. Overnight polysomnography with 24h pH-metry was 
      performed before and after 4-8 weeks of PPI treatment (omeprazole once a day, 
      1mg/kg). RESULTS: Of 37 children, 21 were diagnosed with acid GERD where pre- and 
      post-treatment reflux indexes were 14.09+/-1.47 vs. 7.73+/-1.36; (p<0.001). The 
      number of obstructive apneas and hypopneas decreased after PPI treatment, 
      resulting in an AHI reduction from 13.08+/-3.11/h to 8.22+/-2.52/h; (p<0.01). 
      Respiratory response to PPI ranged from complete resolution of OSA (three 
      children with mild OSA; AHI<5/h; 10.31years; 14.29%) to lack of significant AHI 
      change (six children with severe OSA; AHI>10/h; 3.62 years; 28.57%). 
      Post-treatment AHI was predicted by pre-treatment reflux index (adjusted 
      R(2)=0.487; p<0.001). CONCLUSIONS: Reduction of obstructive respiratory events 
      following short-term PPI treatment in children with both GERD and OSAS may 
      suggest a causal relationship between apnea and reflux in some children. 
      Questionnaire screening for GERD in children with OSAS may be of benefit.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Wasilewska, Jolanta
AU  - Wasilewska J
AD  - Department of Pediatrics, Gastroenterology and Allergology, Medical University of 
      Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. 
      jolanta.wasilewska@wp.eu
FAU - Semeniuk, Janusz
AU  - Semeniuk J
FAU - Cudowska, Beata
AU  - Cudowska B
FAU - Klukowski, Mark
AU  - Klukowski M
FAU - Debkowska, Katarzyna
AU  - Debkowska K
FAU - Kaczmarski, Maciej
AU  - Kaczmarski M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gastroesophageal Reflux/*complications/drug therapy/physiopathology
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Omeprazole/*therapeutic use
MH  - Polysomnography
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Respiration/*drug effects
MH  - Sleep Apnea, Obstructive/*complications/physiopathology
MH  - Surveys and Questionnaires
EDAT- 2012/06/23 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/23 06:00
PHST- 2011/12/31 00:00 [received]
PHST- 2012/04/08 00:00 [revised]
PHST- 2012/04/25 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1389-9457(12)00217-1 [pii]
AID - 10.1016/j.sleep.2012.04.016 [doi]
PST - ppublish
SO  - Sleep Med. 2012 Aug;13(7):824-30. doi: 10.1016/j.sleep.2012.04.016. Epub 2012 Jun 
      20.