PMID- 22721938 OWN - NLM STAT- MEDLINE DCOM- 20121116 LR - 20161125 IS - 1873-4030 (Electronic) IS - 1350-4533 (Linking) VI - 34 IP - 6 DP - 2012 Jul TI - New paradigms in internal architecture design and freeform fabrication of tissue engineering porous scaffolds. PG - 762-76 LID - 10.1016/j.medengphy.2012.05.008 [doi] AB - Advanced additive manufacture (AM) techniques are now being developed to fabricate scaffolds with controlled internal pore architectures in the field of tissue engineering. In general, these techniques use a hybrid method which combines computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to design and fabricate complicated three-dimensional (3D) scaffold models. The mathematical descriptions of micro-architectures along with the macro-structures of the 3D scaffold models are limited by current CAD technologies as well as by the difficulty of transferring the designed digital models to standard formats for fabrication. To overcome these difficulties, we have developed an efficient internal pore architecture design system based on triply periodic minimal surface (TPMS) unit cell libraries and associated computational methods to assemble TPMS unit cells into an entire scaffold model. In addition, we have developed a process planning technique based on TPMS internal architecture pattern of unit cells to generate tool paths for freeform fabrication of tissue engineering porous scaffolds. CI - Copyright (c) 2012 IPEM. Published by Elsevier Ltd. All rights reserved. FAU - Yoo, Dongjin AU - Yoo D AD - Department of Computer Aided Mechanical Design Engineering, Daejin University, Sundan-dong, Pocheon-si, Republic of Korea. djyoo@daejin.ac.kr LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120619 PL - England TA - Med Eng Phys JT - Medical engineering & physics JID - 9422753 SB - IM MH - Algorithms MH - *Computer-Aided Design MH - Mechanical Phenomena MH - Models, Anatomic MH - Porosity MH - Tissue Engineering/*methods MH - *Tissue Scaffolds EDAT- 2012/06/23 06:00 MHDA- 2012/12/10 06:00 CRDT- 2012/06/23 06:00 PHST- 2012/02/29 00:00 [received] PHST- 2012/05/04 00:00 [revised] PHST- 2012/05/11 00:00 [accepted] PHST- 2012/06/23 06:00 [entrez] PHST- 2012/06/23 06:00 [pubmed] PHST- 2012/12/10 06:00 [medline] AID - S1350-4533(12)00128-2 [pii] AID - 10.1016/j.medengphy.2012.05.008 [doi] PST - ppublish SO - Med Eng Phys. 2012 Jul;34(6):762-76. doi: 10.1016/j.medengphy.2012.05.008. Epub 2012 Jun 19.