PMID- 22722049
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20120716
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Sep
TI  - Characteristics of patients suffering from cow milk allergy.
PG  - 94-8
LID - 10.1016/j.intimp.2012.06.008 [doi]
AB  - The most frequent symptoms among the manifestations of cow milk allergy (CMA) are 
      gastrointestinal. CMA pathogenesis involves immunological mechanisms with 
      participation of immunocompetent cells, production of immunoglobulin E (IgE) and 
      immunoglobulin G (IgG). We aim to determine whether cow milk-specific IgE 
      antibodies coexist with cow milk-specific IgG antibodies in CMA patients with 
      diarrhea symptom, and if there is any relationship between both antibody types. 
      65 CMA patients (average age of 17 years, ranging from 2 to 74 years), all of who 
      had diarrhea symptom of CMA, were enrolled in this study. The total cow IgE and 
      IgG subclass in serum were measured by electrochemiluminescence immunoassay and 
      rate immune scatter turbidimetry, respectively. And also the cow milk-specific 
      IgE was determined by enzyme-linked immunosorbent assay. The number of 
      eosinophils in serum was calculated by Sysmex XE-2100 Hematology Analyzer. Our 
      data showed that both cow milk-specific IgG and IgE levels were significantly 
      elevated in CMA patients compared to those of age-matched control subjects. Out 
      of the 65 CMA patients, 40 showed elevated cow milk-specific IgE antibody level, 
      among which, 28 cases presented highly sensitive reaction to cow milk-specific 
      IgG, along with each six of moderate and mild sensitive reaction to cow 
      milk-specific IgG; while 20 showed elevated total IgG levels. The IgG3 positive 
      rate was 16.9%, which was the highest. A moderate correlation between cow 
      milk-specific IgE and cow milk-specific IgG was found in the CMA patients 
      (r=0.415, P=0.001). The results indicated that cow milk-specific IgE antibodies 
      could coexist with cow milk-specific IgG antibodies in patients suffering from 
      CMA. The aberrant changes in the concentration of cow milk-specific IgE 
      antibodies were associated with cow milk-specific IgG antibodies.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Liu, Li-Li
AU  - Liu LL
AD  - Center of Clinical Laboratory, Zhongshan Hospital, Medical College of Xiamen 
      University, Xiamen 361004, China.
FAU - Yao, Hong
AU  - Yao H
FAU - Zhang, Xiao-Ling
AU  - Zhang XL
FAU - Zhang, Hui-Lin
AU  - Zhang HL
FAU - Chao, Peng-Li
AU  - Chao PL
FAU - Tong, Man-Li
AU  - Tong ML
FAU - Liu, Gui-Li
AU  - Liu GL
FAU - Lin, Li-Rong
AU  - Lin LR
FAU - Fan-Liu
AU  - Fan-Liu
FAU - Zhang, Zhong-Ying
AU  - Zhang ZY
FAU - Yang, Tian-Ci
AU  - Yang TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120618
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Immunoglobulin G)
RN  - 0 (Milk Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Cattle
MH  - Child
MH  - Child, Preschool
MH  - Diarrhea/blood/etiology/*immunology
MH  - Eosinophils/*immunology
MH  - Female
MH  - Humans
MH  - *Immunoglobulin E/blood/immunology
MH  - *Immunoglobulin G/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Milk Hypersensitivity/blood/complications/*immunology
MH  - Milk Proteins/immunology
MH  - Young Adult
EDAT- 2012/06/23 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/02/03 00:00 [received]
PHST- 2012/06/05 00:00 [revised]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1567-5769(12)00177-4 [pii]
AID - 10.1016/j.intimp.2012.06.008 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2012 Sep;14(1):94-8. doi: 10.1016/j.intimp.2012.06.008. Epub 
      2012 Jun 18.