PMID- 22723707
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 25
DP  - 2012 Jun 20
TI  - Behavior-related pauses in simple-spike activity of mouse Purkinje cells are 
      linked to spike rate modulation.
PG  - 8678-85
LID - 10.1523/JNEUROSCI.4969-11.2012 [doi]
AB  - Purkinje cells (PCs) in the mammalian cerebellum express high-frequency 
      spontaneous activity with average spike rates between 30 and 200 Hz. Cerebellar 
      nuclear (CN) neurons receive converging input from many PCs, resulting in a 
      continuous barrage of inhibitory inputs. It has been hypothesized that pauses in 
      PC activity trigger increases in CN spiking activity. A prediction derived from 
      this hypothesis is that pauses in PC simple-spike activity represent relevant 
      behavioral or sensory events. Here, we asked whether pauses in the simple-spike 
      activity of PCs related to either fluid licking or respiration, play a special 
      role in representing information about behavior. Both behaviors are widely 
      represented in cerebellar PC simple-spike activity. We recorded PC activity in 
      the vermis and lobus simplex of head-fixed mice while monitoring licking and 
      respiratory behavior. Using cross-correlation and Granger causality analysis, we 
      examined whether short interspike intervals (ISIs) had a different temporal 
      relationship to behavior than long ISIs or pauses. Behavior-related simple-spike 
      pauses occurred during low-rate simple-spike activity in both licking- and 
      breathing-related PCs. Granger causality analysis revealed causal relationships 
      between simple-spike pauses and behavior. However, the same results were obtained 
      from an analysis of surrogate spike trains with gamma ISI distributions 
      constructed to match rate modulations of behavior-related Purkinje cells. Our 
      results therefore suggest that the occurrence of pauses in simple-spike activity 
      does not represent additional information about behavioral or sensory events that 
      goes beyond the simple-spike rate modulations.
FAU - Cao, Ying
AU  - Cao Y
AD  - Department of Anatomy and Neurobiology, University of Tennessee Health Science 
      Center, Memphis, Tennessee 38163, USA.
FAU - Maran, Selva K
AU  - Maran SK
FAU - Dhamala, Mukesh
AU  - Dhamala M
FAU - Jaeger, Dieter
AU  - Jaeger D
FAU - Heck, Detlef H
AU  - Heck DH
LA  - eng
GR  - R01 NS060887/NS/NINDS NIH HHS/United States
GR  - R01 NS067201/NS/NINDS NIH HHS/United States
GR  - R01NS060887/NS/NINDS NIH HHS/United States
GR  - R01NS067201/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Causality
MH  - Cerebellar Cortex/physiology
MH  - Cerebellum/physiology
MH  - Data Interpretation, Statistical
MH  - Electrophysiological Phenomena
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Purkinje Cells/*physiology
MH  - Respiration
PMC - PMC3403286
MID - NIHMS388048
EDAT- 2012/06/23 06:00
MHDA- 2012/08/31 06:00
PMCR- 2012/12/20
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
PHST- 2012/12/20 00:00 [pmc-release]
AID - 32/25/8678 [pii]
AID - 3782417 [pii]
AID - 10.1523/JNEUROSCI.4969-11.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Jun 20;32(25):8678-85. doi: 10.1523/JNEUROSCI.4969-11.2012.