PMID- 22725956
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20231105
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 248
IP  - 1
DP  - 2012 Jul
TI  - The genetics of multiple sclerosis: an up-to-date review.
PG  - 87-103
LID - 10.1111/j.1600-065X.2012.01134.x [doi]
AB  - Multiple sclerosis (MS) is a prevalent inflammatory disease of the central 
      nervous system that often leads to disability in young adults. Treatment options 
      are limited and often only partly effective. The disease is likely caused by a 
      complex interaction between multiple genes and environmental factors, leading to 
      inflammatory-mediated central nervous system deterioration. A series of genomic 
      studies have confirmed a central role for the immune system in the development of 
      MS, including genetic association studies that have now dramatically expanded the 
      roster of MS susceptibility genes beyond the longstanding human leukocyte antigen 
      (HLA) association in MS first identified nearly 40 years ago. Advances in 
      technology together with novel models for collaboration across research groups 
      have enabled the discovery of more than 50 non-HLA genetic risk factors 
      associated with MS. However, with a large proportion of the disease heritability 
      still unaccounted for, current studies are now geared towards identification of 
      causal alleles, associated pathways, epigenetic mechanisms, and gene-environment 
      interactions. This article reviews recent efforts in addressing the genetics of 
      MS and the challenges posed by an ever increasing amount of analyzable data, 
      which is spearheading development of novel statistical methods necessary to cope 
      with such complexity.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
AD  - Department of Neurology, University of California San Francisco, San Francisco, 
      CA 94143-0435, USA.
FAU - Harbo, Hanne F
AU  - Harbo HF
FAU - Hauser, Stephen L
AU  - Hauser SL
FAU - Baranzini, Sergio E
AU  - Baranzini SE
LA  - eng
GR  - R01 NS026799/NS/NINDS NIH HHS/United States
GR  - R01 NS092835/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Environment
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics/immunology
MH  - Humans
MH  - Multiple Sclerosis/*genetics/immunology/metabolism
PMC - PMC5967887
MID - NIHMS968263
EDAT- 2012/06/26 06:00
MHDA- 2012/10/25 06:00
PMCR- 2018/05/24
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
PHST- 2018/05/24 00:00 [pmc-release]
AID - 10.1111/j.1600-065X.2012.01134.x [doi]
PST - ppublish
SO  - Immunol Rev. 2012 Jul;248(1):87-103. doi: 10.1111/j.1600-065X.2012.01134.x.