PMID- 22727437
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20151119
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 60
IP  - 5
DP  - 2012 Nov
TI  - Elevated serum osteoprotegerin levels predict in-hospital major adverse cardiac 
      events in patients with ST elevation myocardial infarction.
PG  - 355-60
LID - S0914-5087(12)00104-9 [pii]
LID - 10.1016/j.jjcc.2012.05.010 [doi]
AB  - The aim of our study was to investigate whether osteoprotegerin (OPG) is related 
      to in-hospital major adverse cardiac events (MACE) and reperfusion parameters in 
      patients with ST elevation myocardial infarction (STEMI). The OPG/receptor 
      activator of nuclear factor-kappaB (RANK)/RANK ligand pathway has recently been 
      associated with atherosclerosis. OPG is a predictor of cardiovascular events in 
      patients with acute coronary syndrome. This study included 96 consecutive 
      patients with STEMI undergoing primary percutaneous coronary intervention (PCI). 
      Two groups with equal number of patients were formed according to median OPG 
      level. The association of OPG levels on admission with post-procedural 
      reperfusion parameters, and in-hospital MACE were investigated. Patients with 
      higher OPG levels displayed higher neutrophil/lymphocyte ratio, admission 
      troponin, admission glucose, and high-sensitive C-reactive protein. Higher OPG 
      levels were associated with increased thrombolysis in myocardial infarction 
      (TIMI) risk score, TIMI risk index, pain to balloon time, need for inotropic 
      support, shock, and MACE, mainly driven by death. Reperfusion parameters were not 
      different between the two groups. TIMI risk score, TIMI risk index, myocardial 
      blush grade, estimated glomerular filtration rate (eGFR), number of obstructed 
      vessels, and OPG significantly predicted adverse cardiac events. Multiple 
      logistic regression analysis revealed OPG as an independent predictor of MACE as 
      well as eGFR, number of obstructed vessels, and corrected TIMI frame count. OPG, 
      a bidirectional molecule displaying both atheroprotective and pro-atherosclerotic 
      properties, is currently known as a marker of inflammation and a predictor of 
      cardiovascular mortality. The present study, for the first time, demonstrated 
      that an increased OPG level is related to in-hospital adverse cardiovascular 
      events after primary PCI in patients with STEMI.
CI  - Copyright (c) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Canga, Aytun
AU  - Canga A
AD  - Rize Education and Research Hospital, Department of Cardiology, Rize, Turkey.
FAU - Durakoglugil, Murtaza Emre
AU  - Durakoglugil ME
FAU - Erdogan, Turan
AU  - Erdogan T
FAU - Kirbas, Aynur
AU  - Kirbas A
FAU - Yilmaz, Adnan
AU  - Yilmaz A
FAU - Cicek, Yuksel
AU  - Cicek Y
FAU - Ergul, Elif
AU  - Ergul E
FAU - Cetin, Mustafa
AU  - Cetin M
FAU - Kocaman, Sinan Altan
AU  - Kocaman SA
LA  - eng
PT  - Journal Article
DEP - 20120621
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Biomarkers)
RN  - 0 (Osteoprotegerin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - *Electrocardiography
MH  - Female
MH  - Forecasting
MH  - *Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/*mortality/therapy
MH  - Osteoprotegerin/*blood
MH  - Percutaneous Coronary Intervention
MH  - Prospective Studies
EDAT- 2012/06/26 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/03/29 00:00 [received]
PHST- 2012/04/23 00:00 [revised]
PHST- 2012/05/12 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S0914-5087(12)00104-9 [pii]
AID - 10.1016/j.jjcc.2012.05.010 [doi]
PST - ppublish
SO  - J Cardiol. 2012 Nov;60(5):355-60. doi: 10.1016/j.jjcc.2012.05.010. Epub 2012 Jun 
      21.