PMID- 22727564
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20191210
IS  - 1618-1433 (Electronic)
IS  - 0940-2993 (Linking)
VI  - 65
IP  - 5
DP  - 2013 Jul
TI  - Prenatal prochloraz treatment significantly increases pregnancy length and 
      reduces offspring weight but does not affect social-olfactory memory in rats.
PG  - 591-3
LID - S0940-2993(12)00059-0 [pii]
LID - 10.1016/j.etp.2012.06.001 [doi]
AB  - Metabolites of the commonly used imidazole fungicide prochloraz are androgen 
      receptor antagonists. They have been shown to block androgen-driven development 
      and compromise reproductive function. We tested the effect of prochloraz on 
      cognitive behavior following exposure to this fungicide during the perinatal 
      period. Pregnant Wistar rats were administered a 200 mg/kg dose of prochloraz on 
      gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was 
      performed on 7-week-old male rat offspring. We found an increase in pregnancy 
      length and a significantly reduced pup weight on PND15 and PND40 but no effect of 
      prenatal prochloraz exposure on social investigation or acquisition of 
      social-olfactory memory.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Dmytriyeva, Oksana
AU  - Dmytriyeva O
AD  - Protein Laboratory, Institute of Neuroscience and Pharmacology, Panum Institute, 
      Blegdamsvej 3C, Building 24.2, Copenhagen DK-2200, Denmark. mellis@sund.ku.dk
FAU - Klementiev, Boris
AU  - Klementiev B
FAU - Berezin, Vladimir
AU  - Berezin V
FAU - Bock, Elisabeth
AU  - Bock E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120621
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Imidazoles)
RN  - 99SFL01YCL (prochloraz)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Birth Weight/drug effects
MH  - Body Weight/*drug effects
MH  - Female
MH  - Fungicides, Industrial/*toxicity
MH  - Gestational Age
MH  - Imidazoles/*toxicity
MH  - Male
MH  - Memory/*drug effects
MH  - Pregnancy
MH  - Pregnancy, Prolonged/*chemically induced
MH  - Prenatal Exposure Delayed Effects/*chemically induced/physiopathology/psychology
MH  - Rats
MH  - Rats, Wistar
MH  - Recognition, Psychology/drug effects
MH  - *Social Behavior
EDAT- 2012/06/26 06:00
MHDA- 2014/01/08 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - S0940-2993(12)00059-0 [pii]
AID - 10.1016/j.etp.2012.06.001 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 2013 Jul;65(5):591-3. doi: 10.1016/j.etp.2012.06.001. Epub 
      2012 Jun 21.