PMID- 22729070
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20120906
IS  - 1759-9873 (Electronic)
IS  - 0964-5284 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Sep
TI  - Electroacupuncture enhances motor recovery performance with brain-derived 
      neurotrophic factor expression in rats with cerebral infarction.
PG  - 222-6
LID - 10.1136/acupmed-2011-010126 [doi]
AB  - OBJECTIVE: Electroacupuncture (EA) is a traditional medicine in patients with 
      post-stroke rehabilitation. Brain-derived neurotrophic factor (BDNF) is a potent 
      growth factor involved in recovery following cerebral injury. The aim of the 
      present study was to investigate whether EA increases BDNF levels and facilitates 
      functional recovery. METHODS: Occlusion of the middle cerebral artery was 
      performed in rats (N=12) followed by reperfusion. EA was applied at the GV20 
      (Baihui) acupoint. Motor and sensory functions were monitored on the Garcia scale 
      for 2 weeks. Expressions of BDNF and receptor tyrosine kinase B (trkB) were 
      determined by immunoblotting and immunohistochemistry. RESULTS: Improvement of 
      Garcia scores, particularly in motor performance, were noted in the group with EA 
      stimulation (p<0.05). With EA application, BDNF was elevated in the ischaemic 
      hemisphere with increased numbers of BDNF(+) cells. Increased expression of trkB 
      was also detected. CONCLUSION: These results indicate that EA at GV20 improves 
      motor recovery and stimulates BDNF/trkB expression in rats with cerebral 
      ischaemia.
FAU - Kim, Min-Wook
AU  - Kim MW
AD  - Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, Catholic 
      University, Seoul, Korea.
FAU - Chung, You Chul
AU  - Chung YC
FAU - Jung, Hee Chan
AU  - Jung HC
FAU - Park, Moon-Seo
AU  - Park MS
FAU - Han, Young-Min
AU  - Han YM
FAU - Chung, Yong-An
AU  - Chung YA
FAU - Maeng, Lee-So
AU  - Maeng LS
FAU - Park, Sang-In
AU  - Park SI
FAU - Lim, Jiyeon
AU  - Lim J
FAU - Im, Woo-Seok
AU  - Im WS
FAU - Chung, Jin Young
AU  - Chung JY
FAU - Kim, Minky
AU  - Kim M
FAU - Mook, Inhee
AU  - Mook I
FAU - Kim, Manho
AU  - Kim M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120623
PL  - England
TA  - Acupunct Med
JT  - Acupuncture in medicine : journal of the British Medical Acupuncture Society
JID - 9304117
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Acupuncture Points
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cerebral Infarction/genetics/metabolism/physiopathology/*therapy
MH  - Disease Models, Animal
MH  - *Electroacupuncture
MH  - Humans
MH  - Male
MH  - *Motor Activity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function
EDAT- 2012/06/26 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - acupmed-2011-010126 [pii]
AID - 10.1136/acupmed-2011-010126 [doi]
PST - ppublish
SO  - Acupunct Med. 2012 Sep;30(3):222-6. doi: 10.1136/acupmed-2011-010126. Epub 2012 
      Jun 23.