PMID- 22729861
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20211021
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 748
DP  - 2012
TI  - Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the 
      regulation of cell destiny: respiration, apoptosis, and human disease.
PG  - 237-64
LID - 10.1007/978-1-4614-3573-0_10 [doi]
AB  - The mitochondrial oxidative phosphorylation (OxPhos) system not only generates 
      the vast majority of cellular energy, but is also involved in the generation of 
      reactive oxygen species (ROS), and apoptosis. Cytochrome c (Cytc) and cytochrome 
      c oxidase (COX) represent the terminal step of the electron transport chain 
      (ETC), the proposed rate-limiting reaction in mammals. Cytc and COX show unique 
      regulatory features including allosteric regulation, isoform expression, and 
      regulation through cell signaling pathways. This chapter focuses on the latter 
      and discusses all mapped phosphorylation sites based on the crystal structures of 
      COX and Cytc. Several signaling pathways have been identified that target COX 
      including protein kinase A and C, receptor tyrosine kinase, and inflammatory 
      signaling. In addition, four phosphorylation sites have been mapped on Cytc with 
      potentially large implications due to its multiple functions including apoptosis, 
      a pathway that is overactive in stressed cells but inactive in cancer. The role 
      of COX and Cytc phosphorylation is reviewed in a human disease context, including 
      cancer, inflammation, sepsis, asthma, and ischemia/reperfusion injury as seen in 
      myocardial infarction and ischemic stroke.
FAU - Huttemann, Maik
AU  - Huttemann M
AD  - Wayne State University School of Medicine, Detroit, MI, USA. 
      mhuttema@med.wayne.edu
FAU - Lee, Icksoo
AU  - Lee I
FAU - Grossman, Lawrence I
AU  - Grossman LI
FAU - Doan, Jeffrey W
AU  - Doan JW
FAU - Sanderson, Thomas H
AU  - Sanderson TH
LA  - eng
GR  - R01 GM089900/GM/NIGMS NIH HHS/United States
GR  - GM089900/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Reactive Oxygen Species)
RN  - 9007-43-6 (Cytochromes c)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Apoptosis
MH  - *Cell Respiration
MH  - Cyclic AMP/physiology
MH  - Cytochromes c/*physiology
MH  - Electron Transport Complex IV/*physiology
MH  - Humans
MH  - Inflammation/metabolism
MH  - Membrane Potential, Mitochondrial
MH  - Molecular Sequence Data
MH  - Neoplasms/metabolism
MH  - Phosphorylation
MH  - Protein Kinase C/physiology
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction
PMC - PMC3727645
MID - NIHMS450954
EDAT- 2012/06/26 06:00
MHDA- 2012/09/07 06:00
PMCR- 2013/07/30
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PHST- 2013/07/30 00:00 [pmc-release]
AID - 10.1007/978-1-4614-3573-0_10 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;748:237-64. doi: 10.1007/978-1-4614-3573-0_10.