PMID- 22729947
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20220316
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 109
IP  - 2
DP  - 2012 Sep
TI  - MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in 
      primary central nervous system lymphoma.
PG  - 239-44
LID - 10.1007/s11060-012-0908-2 [doi]
AB  - Diagnosis of primary lymphomas of the central nervous system (PCNSL) largely 
      depends on histopathology of tumor biopsies. Recently, we identified miRNAs 
      detected in the CSF of PCNSL patients as novel non-invasive biomarkers for this 
      disease. In combined analyses of miR-21, miR-19b, and miR-92 CSF levels, it was 
      possible to differentiate PCNSL from other neurological disorders. In the current 
      study, we first confirmed our previous findings in an enlarged PCNSL cohort (n = 
      39; sensitivity 97.4 %). Also, we sought to establish the potential role of CSF 
      miRNAs as biomarkers for disease course monitoring. In sequential miRNA 
      measurements in CSF derived from nine patients with different disease courses, an 
      intriguing correlation of miRNA levels and PCNSL status during treatment and/or 
      disease follow-up was demonstrated. Finally, we demonstrated that miRNA levels in 
      serum of PCNSL patients (n = 14) were not elevated as compared to controls. In 
      summary, this study provides the first evidence that CSF miRNAs have the 
      potential as biomarkers for treatment monitoring and disease follow-up of 
      patients with PCNSL.
FAU - Baraniskin, Alexander
AU  - Baraniskin A
AD  - Department of Medicine, Hematology and Oncology, Ruhr-University of Bochum, 
      Knappschaftskrankenhaus Bochum-Langendreer, In der Schornau 23/25, 44892, Bochum, 
      Germany.
FAU - Kuhnhenn, Jan
AU  - Kuhnhenn J
FAU - Schlegel, Uwe
AU  - Schlegel U
FAU - Schmiegel, Wolf
AU  - Schmiegel W
FAU - Hahn, Stephan
AU  - Hahn S
FAU - Schroers, Roland
AU  - Schroers R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120623
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Biomarkers/blood/*cerebrospinal fluid
MH  - Cell Count
MH  - Central Nervous System Neoplasms/blood/*cerebrospinal fluid
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Lymphoma/*cerebrospinal fluid
MH  - Male
MH  - MicroRNAs/blood/*cerebrospinal fluid/genetics
MH  - RNA, Messenger/blood/cerebrospinal fluid
MH  - Statistics, Nonparametric
EDAT- 2012/06/26 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/05/29 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1007/s11060-012-0908-2 [doi]
PST - ppublish
SO  - J Neurooncol. 2012 Sep;109(2):239-44. doi: 10.1007/s11060-012-0908-2. Epub 2012 
      Jun 23.