PMID- 22730059
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20120828
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Linking)
VI  - 87
IP  - 9
DP  - 2012 Sep
TI  - An unusual case of donor-derived myelodysplastic syndrome following double-unit 
      umbilical cord blood transplantation in acute lymphoblastic leukemia.
PG  - 931-3
LID - 10.1002/ajh.23260 [doi]
AB  - Umbilical cord-blood transplantation is considered an effective treatment 
      strategy for acute lymphoblastic leukemia (ALL) when a human leukocyte antigen 
      (HLA)-matched donor is unavailable. The use of a second unit helps ensure 
      engraftment in larger adults and those with comorbidities, even though only one 
      unit engrafts in most patients. Herein, we present the clinical and laboratory 
      characteristics of a patient who developed donor-derived myelodysplastic syndrome 
      (ddMDS) after double umbilical cord-blood transplantation (dUCB HSCT). To our 
      knowledge, no cases of ddMDS have been described in a patient with a history of 
      ALL in molecular remission after receiving a dUCB HSCT. Current molecular 
      techniques, including analysis of short tandem repeats (STR) and fluorescence in 
      situ hybridization (FISH) allowed us to firmly establish donor origin.
FAU - Cotter, Ryan
AU  - Cotter R
AD  - Division of Hematology-Oncology, The Tisch Cancer Institute, Mount Sinai School 
      of Medicine, New York, NY 10029, USA.
FAU - Najfeld, Vesna
AU  - Najfeld V
FAU - Isola, Luis
AU  - Isola L
FAU - Del Toro, Gustavo
AU  - Del Toro G
FAU - Roman, Elizabeth
AU  - Roman E
FAU - Petersen, Bruce
AU  - Petersen B
FAU - Mascarenhas, John
AU  - Mascarenhas J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120622
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - *Blood Donors
MH  - Chromosome Aberrations
MH  - Cord Blood Stem Cell Transplantation/*adverse effects
MH  - *Fetal Blood/cytology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Myelodysplastic Syndromes/*etiology/genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics/*therapy
MH  - Tandem Repeat Sequences
EDAT- 2012/06/26 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 10.1002/ajh.23260 [doi]
PST - ppublish
SO  - Am J Hematol. 2012 Sep;87(9):931-3. doi: 10.1002/ajh.23260. Epub 2012 Jun 22.