PMID- 22731780
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20120813
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 80
IP  - 3
DP  - 2012 Sep
TI  - The HLA-DRB1 gene and Graves disease in Taiwanese children: a case-control and 
      family-based study.
PG  - 224-30
LID - 10.1111/j.1399-0039.2012.01920.x [doi]
AB  - Graves disease (GD) is an autoimmune thyroid disease with a female preponderance 
      and a wide range of ages at onset, and human leukocyte antigen (HLA) gene plays a 
      primary role in the susceptibility to GD. We aim to investigate the associations 
      between HLA-DRB1 alleles and Taiwanese children with GD by both case-control and 
      family-based studies. A total of 241 unrelated children with GD, 539 healthy 
      controls, 115 trios of affected patients and their parents, and 121 trios of 
      unaffected siblings and their parents were recruited. HLA-DRB1 genotyping was 
      performed by polymerase chain reaction and sequence-based typing assays. We found 
      that DRB1*09:01 (OR=2.60, 95% CI 2.02-3.35, Pc=6.55x10(-13)) was associated with 
      GD risk, while DRB1*12:02 (OR=0.32, 95% CI 0.20-0.53, Pc=4.55x10(-5)) was 
      protective against GD. Transmission/disequilibrium test further confirmed an 
      overtransmission of the DRB1*09:01 (OR 3.37, 95% CI 2.13-6.22, Pc=1.0x10(-5)) and 
      an undertransmission of the DRB1*12:02 (OR 0.21, 95% CI 0.05-0.42, 
      Pc=1.7x10(-3)). The findings were similar in females when stratified by gender. 
      In conclusion, our results clearly identify that HLA-DRB1*09:01 confers 
      susceptibility to GD and DRB1*12:02 exerts protection against GD development in 
      Taiwanese children.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Wu, Y-L
AU  - Wu YL
AD  - Department of Pediatrics, Mackay Memorial Hospital, and College of Medicine, 
      Taipei Medical University, Taipei, Taiwan.
FAU - Chang, T-Y
AU  - Chang TY
FAU - Chu, C-C
AU  - Chu CC
FAU - Huang, C-Y
AU  - Huang CY
FAU - Lo, F-S
AU  - Lo FS
FAU - Ting, W-H
AU  - Ting WH
FAU - Lin, C-H
AU  - Lin CH
FAU - Lin, M
AU  - Lin M
FAU - Chiu, P-C
AU  - Chiu PC
FAU - Lin, C-L
AU  - Lin CL
FAU - Chen, W-F
AU  - Chen WF
FAU - Lee, Y-J
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120626
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Amino Acids)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Amino Acids/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Family
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - Graves Disease/*genetics/*immunology
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Siblings
MH  - Taiwan/ethnology
MH  - Young Adult
EDAT- 2012/06/27 06:00
MHDA- 2012/12/13 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/03/04 00:00 [received]
PHST- 2012/05/03 00:00 [revised]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.1111/j.1399-0039.2012.01920.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Sep;80(3):224-30. doi: 10.1111/j.1399-0039.2012.01920.x. 
      Epub 2012 Jun 26.