PMID- 22732109
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20181201
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 34
IP  - 6
DP  - 2012 Jul
TI  - Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in 
      a mouse model of Alzheimer's disease.
PG  - 601-10
LID - 10.1179/1743132812Y.0000000054 [doi]
AB  - OBJECTIVES: To examine and compare the pleiotropic anti-inflammatory effects and 
      the long-term effects of atorvastatin and pitavasatin in mouse model of 
      Alzheimer's disease (AD). METHODS: We examined the effects of two strong statins 
      on senile plaque (SP) size and inflammatory responses in the brain of an amyloid 
      precursor protein (APP) transgenic (Tg) mouse. We gave the Tg mice either 
      atorvastatin or pitavastatin from 5-20 months of age, and performed 
      immunohistological analysis [SP area, monocyte chemotactic protein 1 
      (MCP-1)-positive neurons, ionized calcium-binding adaptor molecule 1 
      (Iba-1)-1-positive microglia, and tumor necrosis factor alpha (TNF-alpha)-positive 
      neurons] every 5 months. RESULTS: In the APP-Tg mice treated with both statins, 
      the number of MCP-1-positive neurons was reduced at 10 months, that of 
      Iba-1-positive microglia was reduced at 15 months, and that of TNF-alpha-positive 
      neurons and the mean total SP area decreased at 15-20 months, compared with 
      APP-Tg mice with vehicle treatment. DISCUSSION: The protective effect of these 
      statins took 5 months to reach significance in these mice, and the order of 
      sensitivity to statin treatment was MCP-1>Iba-1>TNF-alpha>SPs. Proinflammatory 
      responses including MCP-1, Iba-1, and TNF-alpha preceded and possibly contributed to 
      SP formation. Pitavastatin has the same significant pleiotrophic effect to 
      prevent and ameliorate inflammation and also has a long-term effect compared with 
      atorvastatin, and both of them have high potential for a preventative approach in 
      patients at risk of AD.
FAU - Kurata, Tomoko
AU  - Kurata T
AD  - Okayama University, Japan.
FAU - Miyazaki, Kazunori
AU  - Miyazaki K
FAU - Kozuki, Miki
AU  - Kozuki M
FAU - Morimoto, Nobutoshi
AU  - Morimoto N
FAU - Ohta, Yasuyuki
AU  - Ohta Y
FAU - Ikeda, Yoshio
AU  - Ikeda Y
FAU - Abe, Koji
AU  - Abe K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120622
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Pyrroles)
RN  - 0 (Quinolines)
RN  - A0JWA85V8F (Atorvastatin)
RN  - M5681Q5F9P (pitavastatin)
SB  - IM
MH  - Alzheimer Disease/metabolism/*pathology
MH  - Animals
MH  - Atorvastatin
MH  - Brain/drug effects/*pathology
MH  - Disease Models, Animal
MH  - Female
MH  - Heptanoic Acids/*pharmacology
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Immunohistochemistry
MH  - Inflammation/metabolism/pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Plaque, Amyloid/metabolism/*pathology
MH  - Pyrroles/*pharmacology
MH  - Quinolines/*pharmacology
EDAT- 2012/06/27 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - ner2815 [pii]
AID - 10.1179/1743132812Y.0000000054 [doi]
PST - ppublish
SO  - Neurol Res. 2012 Jul;34(6):601-10. doi: 10.1179/1743132812Y.0000000054. Epub 2012 
      Jun 22.