PMID- 22732493
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20200930
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 11
IP  - 14
DP  - 2012 Jul 15
TI  - Rapid proliferation of daughter cells lacking particular chromosomes due to 
      multipolar mitosis promotes clonal evolution in colorectal cancer cells.
PG  - 2650-9
LID - 10.4161/cc.20976 [doi]
AB  - Aneuploidy and chromosome instability (CIN) are hallmarks of the vast majority of 
      solid tumors. However, the origins of aneuploid cells are unknown. The aim of 
      this study is to improve our understanding of how aneuploidy and/or CIN arise and 
      of karyotype evolution in cancer cells. By using fluorescence in situ 
      hybridization (FISH) on cells after long-term live cell imaging, we demonstrated 
      that most (> 90%) of the newly generated aneuploid cells resulted from multipolar 
      divisions. Multipolar division occurred in mononucleated and binucleated parental 
      cells, resulting in variation of chromosome compositions in daughter cells. These 
      karyotypes can have the same chromosome number as their mother clone or lack a 
      copy of certain chromosomes. Interestingly, daughter cells that lost a chromosome 
      were observed to survive and form clones with shorter cell cycle duration. In our 
      model of cancer cell evolution, the rapid proliferation of daughter cells from 
      multipolar mitosis promotes colonal evolution in colorectal cancer cells.
FAU - Yang, Chao
AU  - Yang C
AD  - School of Life Sciences, University of Science and Technology of China, Hefei, 
      Anhui, China.
FAU - Shi, Xiaoyun
AU  - Shi X
FAU - Huang, Yun
AU  - Huang Y
FAU - Zhang, Zhen
AU  - Zhang Z
FAU - Cooke, Howard J
AU  - Cooke HJ
FAU - Wang, Mingrong
AU  - Wang M
FAU - Shi, Qinghua
AU  - Shi Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120715
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
SB  - IM
MH  - *Aneuploidy
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Chromosomal Instability
MH  - Chromosomes/*metabolism
MH  - Clonal Evolution
MH  - Colorectal Neoplasms/metabolism/pathology
MH  - HCT116 Cells
MH  - HT29 Cells
MH  - Humans
MH  - Karyotyping
MH  - *Mitosis
EDAT- 2012/06/27 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 20976 [pii]
AID - 10.4161/cc.20976 [doi]
PST - ppublish
SO  - Cell Cycle. 2012 Jul 15;11(14):2650-9. doi: 10.4161/cc.20976. Epub 2012 Jul 15.