PMID- 22732734
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20220409
IS  - 1753-4267 (Electronic)
IS  - 1753-4259 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Feb
TI  - Dendritic cells and their role in tumor immunosurveillance.
PG  - 98-111
LID - 10.1177/1753425912449549 [doi]
AB  - Dendritic cells (DCs) comprise a heterogeneous population of cells that play a 
      key role in initiating, directing and regulating adaptive immune responses, 
      including those critically involved in tumor immunosurveillance. As a riposte to 
      the central role of DCs in the generation of antitumor immune responses, tumors 
      have developed various mechanisms which impair the immunostimulatory functions of 
      DCs or even instruct them to actively contribute to tumor growth and progression. 
      In the first part of this review we discuss general aspects of DC biology, 
      including their origin, subtypes, immature and mature states, and functional 
      plasticity which ensures a delicate balance between active immune response and 
      immune tolerance. In the second part of the review we discuss the complex 
      interactions between DCs and the tumor microenvironment, and point out the 
      challenges faced by DCs during the recognition of tumor Ags. We also discuss the 
      role of DCs in tumor angiogenesis and vasculogenesis.
FAU - Strioga, Marius
AU  - Strioga M
AD  - Department of Immunology, Center of Oncosurgery, Institute of Oncology, Vilnius 
      University, Vilnius, Lithuania. marius.strioga@vuoi.it
FAU - Schijns, Virgil
AU  - Schijns V
FAU - Powell, Daniel J Jr
AU  - Powell DJ Jr
FAU - Pasukoniene, Vita
AU  - Pasukoniene V
FAU - Dobrovolskiene, Neringa
AU  - Dobrovolskiene N
FAU - Michalek, Jaroslav
AU  - Michalek J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120625
PL  - United States
TA  - Innate Immun
JT  - Innate immunity
JID - 101469670
SB  - IM
MH  - Animals
MH  - Cell Communication
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity
MH  - *Monitoring, Immunologic
MH  - Neoplasms/*immunology
MH  - Neovascularization, Pathologic
MH  - Tumor Microenvironment
EDAT- 2012/06/27 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 1753425912449549 [pii]
AID - 10.1177/1753425912449549 [doi]
PST - ppublish
SO  - Innate Immun. 2013 Feb;19(1):98-111. doi: 10.1177/1753425912449549. Epub 2012 Jun 
      25.