PMID- 22733265
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20211021
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 8
IP  - 10
DP  - 2012 Oct
TI  - Metabolic neuroimaging of the brain in diabetes mellitus and hypoglycaemia.
PG  - 588-97
LID - 10.1038/nrendo.2012.97 [doi]
AB  - Functional neuroimaging techniques can be used to study changes in regional brain 
      activation, using changes in surrogate markers such as regional cerebral 
      perfusion and rates of glucose uptake or metabolism. These approaches are 
      shedding new light on two major health problems: the increasing burden of type 2 
      diabetes mellitus (T2DM), which is driven by the rising prevalence of insulin 
      resistance and obesity; and recurrent intractable problematic hypoglycaemia, 
      which is driven by the cognitive impairment that can occur in association with 
      iatrogenic hypoglycaemic episodes. Some patients with diabetes mellitus lose 
      awareness of being hypoglycaemic, which puts them at risk of severe hypoglycaemia 
      as they are unlikely to take action to prevent the condition worsening. 
      Involvement of corticolimbic brain and centres serving higher executive functions 
      as well as the hypothalamus has been demonstrated in both situations and has 
      implications for therapy. This Review describes the relevant principles of 
      functional neuroimaging techniques and presents data supporting the notion that 
      the dysregulation of central pathways involved in metabolic regulation, reward 
      and appetite could contribute to problematic hypoglycaemia during therapy for 
      diabetes mellitus and to insulin-resistant obesity and T2DM. Understanding these 
      dysregulations could enable the development of novel clinical interventions.
FAU - Cheah, Yee-Seun
AU  - Cheah YS
AD  - Diabetes Research Group, Weston Education Centre, Denmark Hill Campus, King's 
      College London, 10 Cutcombe Road, London SE5 9RJ, UK.
FAU - Amiel, Stephanie A
AU  - Amiel SA
LA  - eng
GR  - 10/0003979/DUK_/Diabetes UK/United Kingdom
GR  - MR/J006742/1/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120626
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
SB  - IM
MH  - Animals
MH  - Brain/*metabolism/physiopathology
MH  - Diabetes Mellitus/*metabolism/physiopathology
MH  - Humans
MH  - Hypoglycemia/*metabolism/physiopathology
MH  - Obesity/metabolism/physiopathology
EDAT- 2012/06/27 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - nrendo.2012.97 [pii]
AID - 10.1038/nrendo.2012.97 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2012 Oct;8(10):588-97. doi: 10.1038/nrendo.2012.97. Epub 2012 
      Jun 26.