PMID- 22735491
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20130408
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 237
IP  - 1
DP  - 2012 Sep
TI  - Behavioral phenotype and BDNF differences related to apoE isoforms and sex in 
      young transgenic mice.
PG  - 116-25
LID - 10.1016/j.expneurol.2012.06.015 [doi]
AB  - Human apolipoprotein E (apoE) plays an important role in lipid transport and 
      distribution, being involved in neurite growth and neuroprotection in the brain. 
      In humans, the apoE4 isoform is a risk factor for developing Azheimer's disease 
      (AD), while apoE2 seems to provide neuroprotection. However, very little 
      information is available on apoE2 genotype. In the present study, we have 
      characterized behavioral and learning phenotypes in young transgenic mice apoE2, 
      apoE3 and apoE4 of both sexes. We have also determined the levels of 
      brain-derived neurotrophic factor (BDNF) and its receptor TrkB in cortex and 
      hippocampus of male and female mice carrying either genotype. Our results show a 
      worse performance of apoE4 and apoE2 mice in the acquisition of a spatial task 
      compared to apoE3 mice, and a worse retention in apoE2 mice compared to the other 
      two genotypes. On the other hand, an increase in the exploration of an 
      open-field, which is compatible with a hyperactive behavior, was found in apoE2 
      females, while a decreased activity was observed in apoE4 mice. Increased BDNF 
      levels in the frontal cortex were observed in apoE2 mice compared to apoE3. These 
      results underscore behavioral differences between apoE genotypes in young mice, 
      as well as the existence of interactions between genotype and gender, providing 
      new valuable information on the apoE2 genotype.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Reverte, Ingrid
AU  - Reverte I
AD  - Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, 
      Universitat Rovira i Virgili, Reus, Spain.
FAU - Klein, Anders Bue
AU  - Klein AB
FAU - Ratner, Cecilia
AU  - Ratner C
FAU - Domingo, Jose L
AU  - Domingo JL
FAU - Colomina, Maria Teresa
AU  - Colomina MT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120624
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Apolipoprotein E2)
RN  - 0 (Apolipoprotein E3)
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Isoforms)
SB  - IM
CIN - Exp Neurol. 2013 Mar;241:1-4. PMID: 23262123
MH  - Age Factors
MH  - Animals
MH  - Apolipoprotein E2/genetics
MH  - Apolipoprotein E3/genetics
MH  - Apolipoprotein E4/genetics
MH  - Apolipoproteins E/biosynthesis/genetics/*physiology
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Female
MH  - Frontal Lobe/physiology
MH  - Genotype
MH  - Hippocampus/physiology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - *Phenotype
MH  - Protein Isoforms/biosynthesis/genetics/physiology
MH  - Sex Characteristics
MH  - Spatial Behavior/physiology
EDAT- 2012/06/28 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/06/28 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/06/14 00:00 [revised]
PHST- 2012/06/16 00:00 [accepted]
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - S0014-4886(12)00257-9 [pii]
AID - 10.1016/j.expneurol.2012.06.015 [doi]
PST - ppublish
SO  - Exp Neurol. 2012 Sep;237(1):116-25. doi: 10.1016/j.expneurol.2012.06.015. Epub 
      2012 Jun 24.