PMID- 22735575
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 222
DP  - 2012 Oct 11
TI  - Strain differences in the effects of chronic corticosterone exposure in the 
      hippocampus.
PG  - 269-80
LID - 10.1016/j.neuroscience.2012.06.017 [doi]
AB  - Stress hormones are thought to be involved in the etiology of depression, in 
      part, because animal models show they cause morphological damage to the brain, an 
      effect that can be reversed by chronic antidepressant treatment. The current 
      study examined two mouse strains selected for naturalistic variation of tissue 
      regeneration after injury for resistance to the effects of chronic corticosterone 
      (CORT) exposure on cell proliferation and neurotrophin mobilization. The wound 
      healer MRL/MpJ and control C57BL/6J mice were implanted subcutaneously with 
      pellets that released CORT for 7 days. MRL/MpJ mice were resistant to reductions 
      of hippocampal cell proliferation by chronic exposure to CORT when compared to 
      vulnerable C57BL/6J mice. Chronic CORT exposure also reduced protein levels of 
      brain-derived neurotrophic factor (BDNF) in the hippocampus of C57BL/6J but not 
      MRL/MpJ mice. CORT pellet exposure increased circulating levels of CORT in the 
      plasma of both strains in a dose-dependent manner although MRL/MpJ mice may have 
      larger changes from baseline. The strains did not differ in circulating levels of 
      corticosterone binding globulin (CBG). There were also no strain differences in 
      CORT levels in the hippocampus, nor did CORT exposure alter glucocorticoid 
      receptor or mineralocorticoid receptor expression in a strain-dependent manner. 
      Strain differences were found in the N-methyl-D-aspartate (NMDA) receptor, and 
      BDNF I and IV promoters. Strain and CORT exposure interacted to alter 
      tropomyosine-receptor-kinase B (TrkB) expression and this may be a potential 
      mechanism protecting MRL/MpJ mice. In addition, differences in the inflammatory 
      response of matrix metalloproteinases (MMPs) may also contribute to these strain 
      differences in resistance to the deleterious effects of CORT to the brain.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Hodes, G E
AU  - Hodes GE
AD  - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, 
      United States.
FAU - Brookshire, B R
AU  - Brookshire BR
FAU - Hill-Smith, T E
AU  - Hill-Smith TE
FAU - Teegarden, S L
AU  - Teegarden SL
FAU - Berton, O
AU  - Berton O
FAU - Lucki, I
AU  - Lucki I
LA  - eng
GR  - R01-MH86599/MH/NIMH NIH HHS/United States
GR  - T32-MH14654/MH/NIMH NIH HHS/United States
GR  - R01 MH086599/MH/NIMH NIH HHS/United States
GR  - T32 MH014654/MH/NIMH NIH HHS/United States
GR  - R01 MH087581/MH/NIMH NIH HHS/United States
GR  - F32 MH093121/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120623
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drug Implants)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 9010-38-2 (Transcortin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation/drug effects
MH  - Corticosterone/administration & dosage/metabolism/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Drug Implants
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Flow Cytometry
MH  - Gene Expression/drug effects
MH  - Hippocampus/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred MRL lpr
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Glucocorticoid/biosynthesis
MH  - Species Specificity
MH  - Transcortin/metabolism
PMC - PMC3587173
MID - NIHMS442312
EDAT- 2012/06/28 06:00
MHDA- 2013/01/25 06:00
PMCR- 2013/03/04
CRDT- 2012/06/28 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/05/18 00:00 [revised]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
PHST- 2013/03/04 00:00 [pmc-release]
AID - S0306-4522(12)00617-3 [pii]
AID - 10.1016/j.neuroscience.2012.06.017 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Oct 11;222:269-80. doi: 10.1016/j.neuroscience.2012.06.017. 
      Epub 2012 Jun 23.