PMID- 2273657
OWN - NLM
STAT- MEDLINE
DCOM- 19910227
LR  - 20181130
IS  - 0301-1542 (Print)
IS  - 0301-1542 (Linking)
VI  - 28
IP  - 10
DP  - 1990 Oct
TI  - [Possible contribution of lung macrophage to airway hyperreactivity].
PG  - 1294-8
AB  - To elucidate the possible contribution of lung macrophage to airway 
      hyperreactivity, we studied the effect of canine pulmonary alveolar macrophages 
      (PAM) stimulated with anti-dinitrophenyl (DNP) IgE antibody and DNP-human serum 
      albumin on airway smooth muscle and epithelial functions in vitro. IgE-stimulated 
      PAM increased the contractile responses of bronchial segments to electrical field 
      stimulation and the short-circuit current of cultured tracheal epithelium, the 
      former effect being abolished in the presence of the thromboxane A2 receptor 
      antagonist and the latter inhibited by the leukotriene antagonist and the Cl 
      transport blocker. These results suggest that PAM may increase the 
      parasympathetic contraction and Cl secretion in the airway through IgE-dependent 
      release of thromboxane A2 and leukotriene, respectively.
FAU - Tamaoki, J
AU  - Tamaoki J
AD  - First Department of Medicine, Tokyo Women's Medical College, Japan.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Kyobu Shikkan Gakkai Zasshi
JT  - Nihon Kyobu Shikkan Gakkai zasshi
JID - 7505737
RN  - 0 (Antigen-Antibody Complex)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4R7X1O2820 (Chlorine)
RN  - 57576-52-0 (Thromboxane A2)
SB  - IM
MH  - Animals
MH  - Antigen-Antibody Complex/immunology
MH  - Bronchi/immunology/metabolism
MH  - Chlorine/metabolism
MH  - Dogs
MH  - Immunoglobulin E/immunology
MH  - In Vitro Techniques
MH  - Macrophages/*immunology/physiology
MH  - Muscle Contraction
MH  - Muscle, Smooth/*immunology/physiology
MH  - Pulmonary Alveoli/*cytology
MH  - Thromboxane A2/metabolism/physiology
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Oct;28(10):1294-8.