PMID- 22737152
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in 
      the maintenance of immune tolerance.
PG  - 165
LID - 10.3389/fimmu.2012.00165 [doi]
LID - 165
AB  - Peripheral immune tolerance requires a controlled balance between the maintenance 
      of self-tolerance and the capacity to engage protective immune responses against 
      pathogens. Dendritic cells (DCs) serve as sentinels of the immune system by 
      sensing environmental and inflammatory signals, and play an essential role in the 
      maintenance of immune tolerance. To achieve this, DC play a key role in dictating 
      the outcome of immune responses by influencing the balance between inflammatory 
      or Foxp3(+) regulatory T (T(reg)) cell responses. At the heart of this 
      immunological balance is a finely regulated DC and T(reg) cell crosstalk whereby 
      T(reg) cells modulate DC phenotype and function, and DC drive the differentiation 
      of Foxp3(+) T(reg) cells in order to control immune responses. This review will 
      focus on recent advances, which highlight the importance of this bidirectional DC 
      and T(reg) cell crosstalk during the induction of tolerance and organ-specific 
      autoimmunity. More specifically, we will discuss how T(reg) cells modulate DC 
      function for the suppression of inflammatory responses and how DC subsets employ 
      diverse mechanisms to drive differentiation of T(reg) cells. Finally, we will 
      discuss the therapeutic potential of tolerogenic DCs for the induction of 
      tolerance in autoimmune diseases.
FAU - Kornete, Mara
AU  - Kornete M
AD  - Department of Microbiology and Immunology, McGill University, Montreal, QC, 
      Canada.
FAU - Piccirillo, Ciriaco A
AU  - Piccirillo CA
LA  - eng
PT  - Journal Article
DEP - 20120622
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3381230
OTO - NOTNLM
OT  - Foxp3
OT  - immunity
OT  - suppression
OT  - tolerance
OT  - tolerogenic DC
EDAT- 2012/06/28 06:00
MHDA- 2012/06/28 06:01
PMCR- 2012/01/01
CRDT- 2012/06/28 06:00
PHST- 2012/04/05 00:00 [received]
PHST- 2012/06/01 00:00 [accepted]
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/06/28 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00165 [doi]
PST - epublish
SO  - Front Immunol. 2012 Jun 22;3:165. doi: 10.3389/fimmu.2012.00165. eCollection 
      2012.