PMID- 22737918
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20120628
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 28
IP  - 2
DP  - 2012 Mar
TI  - [The effects of mesenteric lymph drainage on erythrocyte rheology in rats with 
      hemorrhagic shock].
PG  - 149-53
AB  - OBJECTIVE: To observe the effects of mesenteric lymph drainage on erythrocyte 
      rheology and blood viscosity in hemorrhagic shock rats. METHODS: Wistar rats were 
      randomly divided into sham-shock group, shock group (establishing hemorrhagic 
      shock model), drainage group (establishing hemorrhagic shock model plus 
      drainaging shock mesenteric lymph from hypotension 1 h). At 3 h of hypotension or 
      corresponding time, blood samples were harvested from the abdominal aorta for 
      determining the erythrocytic parameters, erythrocyte electrophoresis, erythrocyte 
      sedimentation rate (ESR) and blood viscosity, and the erythrocytes aggregation 
      index and erythrocyte deformability index were calculated. RESULTS: Compared with 
      the sham-shock group, the red cell contents, hematocrit (HCT), hemoglobin (Hb), 
      mean corpuscular hemoglobin concentration (MCHC), erythrocyte electrophoretic 
      rate and mobility, erythrocyte deformability index, whole blood viscosity, whole 
      blood relative or reduced viscosity at low and high shear rates in shock group 
      were observably lower, and mean corpuscular volume, electrophoretic time of 
      erythrocyte, ESR, K value of equation and K value of emendation, erythrocytes 
      aggregation index, plasma viscosity in shock group were increased markedly; the 
      MCHC, erythrocyte electrophoretic rate and mobility, whole blood viscosity, whole 
      blood relative viscosity at low and high shear rates in drainage group were 
      reduced, and the red blood cell volume distribution width -SD (RDW-SD) was 
      increased remarkably. At the same time, in drainage group, the HCT, RDW-SD, 
      erythrocyte deformability index, whole blood viscosity and relative viscosity at 
      low and high shear rates were higher, the ESR, K value of equation and K value of 
      emendation, erythrocytes aggregation index, plasma viscosity were lower than that 
      of shock group. CONCLUSION: The results indicate that the mesenteric lymph 
      drainage could improve the erythrocyte rheological behavior, as a result, improve 
      the hemorrheological properties in hemorrhagic shock rats.
FAU - Zhao, Zi-Gang
AU  - Zhao ZG
AD  - Institute of Microcirculation, Hebei North University, Zhangjiakou 075029, China.
FAU - Nju, Chun-Yu
AU  - Nju CY
FAU - Hi, Zhi-Peng
AU  - Hi ZP
FAU - Zhang, Min
AU  - Zhang M
FAU - Xu, Guo-Jie
AU  - Xu GJ
FAU - Jiang, Hua
AU  - Jiang H
FAU - Zhang, Jing
AU  - Zhang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
SB  - IM
MH  - Animals
MH  - Blood Viscosity
MH  - Drainage/methods
MH  - Erythrocyte Aggregation
MH  - *Erythrocyte Deformability
MH  - Lymph
MH  - Male
MH  - Mesentery
MH  - Rats
MH  - Rats, Wistar
MH  - Rheology
MH  - Shock, Hemorrhagic/*blood/*therapy
EDAT- 2012/06/29 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):149-53.