PMID- 22738419
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20220330
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 24
IP  - 5
DP  - 2013
TI  - The relationship between iron parameters and platelet parameters in women with 
      iron deficiency anemia and thrombocytosis.
PG  - 348-51
LID - 10.3109/09537104.2012.699641 [doi]
AB  - Changes of platelet count (PLT) and platelet parameters have been reported in 
      iron deficiency anemia (IDA). However, the relationship between iron metabolism 
      and thrombopoiesis is not yet fully known. We studied the relationship between 
      iron and platelet parameters in women with IDA and thrombocytosis. Forty-one 
      adult women with IDA and thrombocytosis were enrolled. The relationship between 
      iron parameters (such as serum iron, serum ferritin, total iron-binding capacity 
      (TIBC)C, and transferrin saturation (Tfsat)), and platelet parameters (PLT, 
      platelet crit (PCT), mean platelet volume (MPV), mean platelet component (MPC), 
      mean platelet mass, platelet distribution width, and large platelet (LPLT)), 
      which measured with CBC on ADVIA, were investigated. In addition, the difference 
      in platelet and iron parameters between severe IDA (Hb < 7 g/dl) and non-severe 
      IDA were compared. PLT inversely correlated with serum iron and Tfsat (p < 0.05). 
      Serum iron and TIBC revealed no significant relationships with any platelet 
      parameters. PLT, PCT, and MPV inversely correlated with mean corpuscular 
      hemoglobin concentration (MCHC) but MPC exhibited linear correlation with Hb, 
      hematocrit, and MCHC (p < 0.05). PCT had linear correlation with PLT and MPV 
      (p < 0.001), whereas PCT, MPV, and LPLT (p < 0.001 for two formers, p < 0.05) 
      inversely correlated with MPC. In this study, the important iron parameters 
      affecting PLT were serum iron and Tfsat. In addition, patients with more severe 
      and hypochromic anemia had higher PLT, PCT, and MPV.
FAU - Park, Mi-Jung
AU  - Park MJ
AD  - Departments of Laboratory Medicine, Gachon University Gil Medical Center, 
      Incheon, Korea.
FAU - Park, Pil-Whan
AU  - Park PW
FAU - Seo, Yiel-Hea
AU  - Seo YH
FAU - Kim, Kyung-Hee
AU  - Kim KH
FAU - Park, Soon-Ho
AU  - Park SH
FAU - Jeong, Ji-Hun
AU  - Jeong JH
FAU - Ahn, Jeong-Yeal
AU  - Ahn JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120627
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anemia, Iron-Deficiency/blood/etiology/*metabolism
MH  - Erythrocyte Indices
MH  - Female
MH  - Humans
MH  - Iron/blood/*metabolism
MH  - Middle Aged
MH  - *Platelet Count
MH  - Platelet Function Tests
MH  - Thrombocytosis/blood/etiology/*metabolism
EDAT- 2012/06/29 06:00
MHDA- 2014/01/31 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - 10.3109/09537104.2012.699641 [doi]
PST - ppublish
SO  - Platelets. 2013;24(5):348-51. doi: 10.3109/09537104.2012.699641. Epub 2012 Jun 
      27.