PMID- 22740022
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20120831
IS  - 2240-2993 (Electronic)
IS  - 0300-9009 (Linking)
VI  - 112
IP  - 3
DP  - 2012 Sep
TI  - Serum brain-derived neurotrophic factor, nerve growth factor and neurotrophin-3 
      levels in dementia.
PG  - 255-60
LID - 10.1007/s13760-012-0101-6 [doi]
AB  - The aim of this study is to measure serum levels of neurotropic factor (NF) in 
      patients with dementia. Brain-derived neurotrophic factor (BDNF), nerve growth 
      factor (NGF), and neurotrophin-3 (NT-3) were determined in Alzheimer's dementia 
      patients without medication (AD; n: 22), Alzheimer's dementia patients receiving 
      cholinesterase inhibitor (CEI) treatment (AD + CEI; n: 32) and vascular dementia 
      patients receiving CEI treatment (VaD + CEI; n: 27) and the age-matched control 
      group (n: 20). NGF levels were detected to be significantly higher in the control 
      group than in AD group (P < 0.001). BDNF and NT-3 levels in AD group were not 
      significantly different from control group's levels. NGF levels in AD + CEI group 
      were significantly higher than in AD group (P < 0.05). There was also no 
      significant difference in serum neurotrophic factor levels between AD + CEI and 
      VaD + CEI group. A positive correlation between BDNF and Mini Mental State 
      Examination (MMSE) scores (r: 0.422, P < 0.01) in AD group and a negative 
      correlation between BDNF and MMSE scores in the AD + CEI group (r: -0.357, 
      P < 0.005) were obtained. In conclusion, our results suggest that while serum NGF 
      levels are associated with the presence of dementia, serum BDNF levels may be 
      associated with the severity of Alzheimer's dementia. However, future studies are 
      required to determine the importance of NFs.
FAU - Konukoglu, Dildar
AU  - Konukoglu D
AD  - Atakoy Konaklari, D2-1, Daire 10, Bakirkoy, Istanbul, Turkey. dkonuk@yahoo.com
FAU - Andican, Gulnur
AU  - Andican G
FAU - Firtina, Sinem
AU  - Firtina S
FAU - Erkol, Gokhan
AU  - Erkol G
FAU - Kurt, Asuman
AU  - Kurt A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - Italy
TA  - Acta Neurol Belg
JT  - Acta neurologica Belgica
JID - 0247035
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Dementia/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Status Schedule
MH  - Middle Aged
MH  - Nerve Growth Factor/*blood
MH  - Neurotrophin 3/*blood
EDAT- 2012/06/29 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/06/29 06:00
PHST- 2011/10/08 00:00 [received]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.1007/s13760-012-0101-6 [doi]
PST - ppublish
SO  - Acta Neurol Belg. 2012 Sep;112(3):255-60. doi: 10.1007/s13760-012-0101-6. Epub 
      2012 Jun 28.