PMID- 22740140
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 11
DP  - 2012 Nov
TI  - The polymorphism analysis of CD169 and CD163 related with the risk of porcine 
      reproductive and respiratory syndrome virus (PRRSV) infection.
PG  - 9903-9
AB  - Porcine reproductive and respiratory syndrome virus (PRRSV) could infect porcine 
      alveolar macrophages (PAM), and the CD169 and CD163 are identified as critical 
      receptors on the surface of PAM, but whether the single nucleotide polymorphisms 
      (SNPs) of these genes could influence the infection is remain unclear. In this 
      study, we identified totally 6 SNPs for CD169 (G1640T, C1654A, C4175T) and CD163 
      (G2277A, A2552G and C2700A), and evaluated their associations with PRRSV 
      infection using two classified methods in a 524 pig population to investigate the 
      effects of mutations on the PRRSV receptors. The pigs with genotypes of AA of 
      CD169-C1654A, CT of CD169-C4175T and AA of CD163-A2552G appeared to resistant to 
      the PRRSV infection by the combination of two classified results. The results 
      provided fundamental molecular investigation to promote pig breeding with disease 
      resistance. However, the identification of functional changes induced by SNPs and 
      molecular mechanism were need further research.
FAU - Ren, Y W
AU  - Ren YW
AD  - Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of 
      Ministry of Education, Huazhong Agriculture University, Hubei, 430070 Wuhan, 
      China.
FAU - Zhang, Y Y
AU  - Zhang YY
FAU - Affara, N A
AU  - Affara NA
FAU - Sargent, C A
AU  - Sargent CA
FAU - Yang, L G
AU  - Yang LG
FAU - Zhao, J L
AU  - Zhao JL
FAU - Fang, L R
AU  - Fang LR
FAU - Wu, J J
AU  - Wu JJ
FAU - Fang, R
AU  - Fang R
FAU - Tong, Q
AU  - Tong Q
FAU - Xiao, J
AU  - Xiao J
FAU - Li, J L
AU  - Li JL
FAU - Jiang, Y B
AU  - Jiang YB
FAU - Chen, H C
AU  - Chen HC
FAU - Zhang, S J
AU  - Zhang SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD163 antigen)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 1)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/*genetics
MH  - Antigens, Differentiation, Myelomonocytic/*genetics
MH  - Cell Line
MH  - Genotype
MH  - Macrophages, Alveolar/virology
MH  - *Polymorphism, Single Nucleotide
MH  - Porcine Reproductive and Respiratory Syndrome/*virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*physiology
MH  - Receptors, Cell Surface/*genetics
MH  - Sialic Acid Binding Ig-like Lectin 1/*genetics
MH  - Swine
MH  - Viral Proteins/*genetics
EDAT- 2012/06/29 06:00
MHDA- 2013/06/28 06:00
CRDT- 2012/06/29 06:00
PHST- 2011/10/19 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
AID - 10.1007/s11033-012-1857-8 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Nov;39(11):9903-9. doi: 10.1007/s11033-012-1857-8. Epub 2012 
      Jun 28.