PMID- 22740299
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20161125
IS  - 1469-0705 (Electronic)
IS  - 0960-7692 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Sep
TI  - Axonal loss and cognitive deficits in term infants with normal umbilical artery 
      Doppler born small-for-gestational age.
PG  - 297-303
LID - 10.1002/uog.11215 [doi]
AB  - OBJECTIVE: To assess cognitive outcomes and structural changes in the central 
      nervous system, the latter using a novel approach to examine changes in neuronal 
      integrity of the optic nerve, in children at 5-6(1/2) years of age who were born 
      small-for-gestational age (SGA) at term having shown normal umbilical artery (UA) 
      Doppler. METHODS: We compared neuronal damage, cognitive deficits and 
      visuospatial perception in two cohorts of infants, one born SGA (n = 40) and one 
      born appropriate-for-gestational age (AGA) (n = 39) in weight. Neuronal damage 
      was evaluated using optical coherence tomography (OCT) of the optic nerve. 
      Cognitive deficits were assessed with the Wechsler Preschool and Primary Scale of 
      Intelligence (WPPSI) test. Visuospatial perception was evaluated with 
      Rey-Osterreich Complex Figure (ROCF) tasks. RESULTS: Children from the SGA group 
      had a significantly thinner average retinal nerve fiber layer (RNFL) compared 
      with those from the AGA group (98.2 vs 104.5 microm, P = 0.012). Children from the 
      SGA group exhibited impaired performance in copy tasks on the ROCF (3.27 vs 3.56, 
      P = 0.036) and a higher rate of suboptimal WPPSI test performance intelligence 
      quotient scores (15% vs 0%; P = 0.025) compared with those from the AGA group. 
      CONCLUSION: Term infants with normal UA Doppler born SGA are at increased risk 
      for cognitive deficits and axonal loss in the RNFL at the age of 5-6(1/2) years.
CI  - Copyright (c) 2012 ISUOG. Published by John Wiley & Sons, Ltd.
FAU - Pueyo, V
AU  - Pueyo V
AD  - Ophthalmology Department, Hospital Universitario Miguel Servet, Zaragoza, Spain. 
      vpueyo@unizar.es
FAU - Oros, D
AU  - Oros D
FAU - Valle, S
AU  - Valle S
FAU - Tuquet, H
AU  - Tuquet H
FAU - Guerri, N
AU  - Guerri N
FAU - Arguelles, M
AU  - Arguelles M
FAU - Ventura, P
AU  - Ventura P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ultrasound Obstet Gynecol
JT  - Ultrasound in obstetrics & gynecology : the official journal of the International 
      Society of Ultrasound in Obstetrics and Gynecology
JID - 9108340
SB  - IM
CIN - Ultrasound Obstet Gynecol. 2012 Sep;40(3):255. PMID: 22911635
MH  - Adult
MH  - Axons/*pathology
MH  - Central Nervous System/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Cognition Disorders/*physiopathology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age
MH  - Optic Nerve/*physiopathology
MH  - Perception
MH  - Tomography, Optical Coherence/*methods
MH  - Ultrasonography, Doppler/*methods
MH  - Ultrasonography, Prenatal
MH  - Umbilical Arteries/*diagnostic imaging
EDAT- 2012/06/29 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - 10.1002/uog.11215 [doi]
PST - ppublish
SO  - Ultrasound Obstet Gynecol. 2012 Sep;40(3):297-303. doi: 10.1002/uog.11215.