PMID- 22742891
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20131121
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 27
IP  - 11
DP  - 2012 Nov
TI  - Community-based cross-sectional study: the association of lipids with hepatitis C 
      seropositivity and diabetes mellitus.
PG  - 1688-94
LID - 10.1111/j.1440-1746.2012.07212.x [doi]
AB  - BACKGROUND AND AIMS: Hepatitis C virus (HCV) infection is reported to be 
      associated with or to cause type 2 diabetes mellitus (T2DM). Our study aimed to 
      elucidate the role of triglyceride (TG) and cholesterol (CHOL) levels in the 
      association between anti-HCV seropositivity and T2DM in an HCV-endemic area. 
      METHODS: We analyzed a computerized dataset of 56 338 residents from a 
      community-based comprehensive screening program in Tainan County in southern 
      Taiwan. Fasting glucose, anti-HCV status, hepatitis B surface antigen (HBsAg) 
      status, platelet counts, TG levels, CHOL levels, age, gender, and body mass index 
      were included in the analyses. Multivariate logistic analysis was used to 
      identify factors independently associated with T2DM. RESULTS: Older age, being 
      overweight, thrombocytopenia, hypertriglyceridemia, hypercholesterolemia, 
      anti-HCV seropositivity, and HBsAg seronegativity were common factors 
      independently associated with diabetes. Among all models of multiple logistic 
      regression analysis used for identifying factors independently associated with 
      T2DM, anti-HCV seropositivity was only identified in the models that included 
      either hypertriglyceridemia or hypercholesterolemia. When subjects were divided 
      into hyperlipidemia (CHOL, > 200 or TG, > 150 mg/dL; n = 33 393) or 
      non-hyperlipidemia subgroups (CHOL, < 200 and TG, < 150 mg/dL; n = 22 945), 
      anti-HCV seropositivity was identified as an independent factor only in the 
      non-hyperlipidemia subgroup. The odds ratio was 1.35, with a 95% confidence 
      interval of 1.17-1.55. CONCLUSIONS: This study demonstrates that the lipid level 
      is associated with the relationship between T2DM and anti-HCV seropositivity in 
      non-hyperlipidemic individuals. However, the relationship between HCV and T2DM 
      did not exist when the lipid level was not included in the analysis.
CI  - (c) 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing 
      Asia Pty Ltd.
FAU - Liu, Ju-Ling
AU  - Liu JL
AD  - Department of Nursing, College of Pharmacy and Health Care, Tajen University, 
      Yenpu, Pingtung, Taiwan.
FAU - Chen, Jing-Yi
AU  - Chen JY
FAU - Chen, Chao-Tung
AU  - Chen CT
FAU - Wang, Jing-Houng
AU  - Wang JH
FAU - Lin, Chih-Yun
AU  - Lin CY
FAU - Chen, Pao-Fei
AU  - Chen PF
FAU - Hung, Chao-Hung
AU  - Hung CH
FAU - Kee, Kwong-Ming
AU  - Kee KM
FAU - Lee, Chuan-Mo
AU  - Lee CM
FAU - Tsai, Lin-San
AU  - Tsai LS
FAU - Chen, Shu-Chuan
AU  - Chen SC
FAU - Lin, Sheng-Che
AU  - Lin SC
FAU - Lu, Sheng-Nan
AU  - Lu SN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Hepatitis C Antibodies)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - J Gastroenterol Hepatol. 2012 Nov;27(11):1647-8. PMID: 23106366
MH  - Aged
MH  - Cholesterol/*blood
MH  - Confidence Intervals
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*epidemiology
MH  - Female
MH  - Health Surveys
MH  - Hepacivirus/immunology
MH  - Hepatitis C/blood/complications/*epidemiology
MH  - Hepatitis C Antibodies/*blood
MH  - Humans
MH  - Hypercholesterolemia/complications/epidemiology
MH  - Hypertriglyceridemia/complications/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Prevalence
MH  - Taiwan/epidemiology
MH  - Triglycerides/*blood
EDAT- 2012/06/30 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 10.1111/j.1440-1746.2012.07212.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2012 Nov;27(11):1688-94. doi: 
      10.1111/j.1440-1746.2012.07212.x.