PMID- 22742936
OWN - NLM
STAT- MEDLINE
DCOM- 20121123
LR  - 20220318
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 88
IP  - 6
DP  - 2012 Sep 1
TI  - Hydrogen-rich saline protects against oxidative damage and cognitive deficits 
      after mild traumatic brain injury.
PG  - 560-5
LID - 10.1016/j.brainresbull.2012.06.006 [doi]
AB  - Oxidative stress is the principal factor in traumatic brain injury (TBI) that 
      initiates events that result in protracted neuronal dysfunction and remodeling. 
      Importantly, antioxidants can protect the brain against oxidative damage and 
      modulate the capacity of the brain to cope with synaptic dysfunction and 
      cognitive impairment. However, no studies have investigated the effects of 
      hydrogen-rich saline on cognitive deficits after TBI. In the present study, rats 
      with fluid percussion injury (FPI) were used to investigate the protective 
      effects of hydrogen-rich saline. The results showed that hydrogen-rich saline 
      reduced the level of malondialdehyde (MDA) and elevated the level of silent 
      information regulator 2 (Sir2). In addition, treatment with hydrogen-rich saline, 
      which elevated the levels of molecules associated with brain-derived neurotropic 
      factor (BDNF)-mediated synaptic plasticity, improved cognitive performance in the 
      Morris water maze after mild TBI. These results suggest that hydrogen-rich saline 
      can protect the brain against the deleterious effects of mild TBI on synaptic 
      plasticity and cognition and that hydrogen-rich saline could be an effective 
      therapeutic strategy for patients with cognitive deficits after TBI.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hou, Zonggang
AU  - Hou Z
AD  - Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, PR 
      China.
FAU - Luo, Wei
AU  - Luo W
FAU - Sun, Xuejun
AU  - Sun X
FAU - Hao, Shuyu
AU  - Hao S
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Xu, Feifan
AU  - Xu F
FAU - Wang, Zhongcheng
AU  - Wang Z
FAU - Liu, Baiyun
AU  - Liu B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120626
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Sirt2 protein, rat)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - EC 3.5.1.- (Sirtuin 2)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage/*therapeutic use
MH  - Brain Injuries/complications/*drug therapy
MH  - Brain-Derived Neurotrophic Factor/physiology
MH  - Cognition Disorders/etiology/*prevention & control
MH  - Drug Evaluation, Preclinical
MH  - Escape Reaction/drug effects
MH  - Hippocampus/chemistry
MH  - Hydrogen/administration & dosage/*therapeutic use
MH  - Lipid Peroxidation/drug effects
MH  - Malondialdehyde/analysis
MH  - Maze Learning/drug effects
MH  - Models, Animal
MH  - Nerve Tissue Proteins/biosynthesis/genetics
MH  - Neuronal Plasticity/drug effects
MH  - Oxidative Stress/drug effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sirtuin 2/biosynthesis/genetics
MH  - Sodium Chloride/administration & dosage
EDAT- 2012/06/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/06/06 00:00 [revised]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0361-9230(12)00148-7 [pii]
AID - 10.1016/j.brainresbull.2012.06.006 [doi]
PST - ppublish
SO  - Brain Res Bull. 2012 Sep 1;88(6):560-5. doi: 10.1016/j.brainresbull.2012.06.006. 
      Epub 2012 Jun 26.