PMID- 22743331
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20161125
IS  - 1878-5875 (Electronic)
IS  - 1357-2725 (Linking)
VI  - 44
IP  - 11
DP  - 2012 Nov
TI  - Foxo3a targets mitochondria during guanosine 5'-triphosphate guided erythroid 
      differentiation.
PG  - 1718-28
LID - S1357-2725(12)00222-1 [pii]
LID - 10.1016/j.biocel.2012.06.023 [doi]
AB  - Evidence is emerging that Foxo family proteins serve as biochemical signal 
      integrators in complex signaling networks mediating and modulating diverse 
      cellular functions. Herein, we report that besides the well-established function 
      of Foxo3a as a transcriptional regulator of multiple target genes in nucleus, a 
      substantial fraction of Foxo3a translocates to mitochondria leading to disruption 
      of mitochondrial membrane potential, release of cytochrome c and caspase 
      activation during erythroid differentiation mediated by guanosine 5'-triphosphate 
      (GTP). In fact, non transcriptional role of Foxo3a in mitochondria was achieved 
      through the protein-protein interaction with pro-apoptotic protein Bax and its 
      translocation to mitochondrial membrane. Furthermore, our results revealed that 
      mitochondrial localization of Foxo3a was modulated by intracellular GTP content 
      which is sensed by PKC signaling element. Collectively, our findings provided 
      insight into a novel Foxo3a mechanism in leukemia cells which led to engagement 
      of cells in the maturation pathway.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Meshkini, Azadeh
AU  - Meshkini A
AD  - Institute of Biochemistry and Biophysics, PO Box 13145-1384, University of 
      Tehran, Tehran, Iran.
FAU - Yazdanparast, Razieh
AU  - Yazdanparast R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120626
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (FOXO3 protein, human)
RN  - 0 (Forkhead Box Protein O3)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 2.7.11.13 (Protein Kinase C-alpha)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Caspases/metabolism
MH  - Cell Differentiation/*drug effects
MH  - Erythroid Cells/*cytology/drug effects/*metabolism
MH  - Forkhead Box Protein O3
MH  - Forkhead Transcription Factors/*metabolism
MH  - Gene Knockdown Techniques
MH  - Guanosine Triphosphate/*pharmacology
MH  - Humans
MH  - Intracellular Space/drug effects/metabolism
MH  - K562 Cells
MH  - Membrane Potential, Mitochondrial/drug effects
MH  - Mitochondria/drug effects/*metabolism
MH  - Protein Kinase C-alpha/antagonists & inhibitors/metabolism
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Protein Transport/drug effects
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2012/06/30 06:00
MHDA- 2013/03/27 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/02/18 00:00 [received]
PHST- 2012/06/13 00:00 [revised]
PHST- 2012/06/15 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
AID - S1357-2725(12)00222-1 [pii]
AID - 10.1016/j.biocel.2012.06.023 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2012 Nov;44(11):1718-28. doi: 
      10.1016/j.biocel.2012.06.023. Epub 2012 Jun 26.