PMID- 2274469
OWN - NLM
STAT- MEDLINE
DCOM- 19910228
LR  - 20131121
IS  - 0301-0244 (Print)
IS  - 0301-0244 (Linking)
VI  - 42
IP  - 2
DP  - 1990 Mar-Apr
TI  - Dissimilar effects of lithium and carbamazepine on erythrocyte lithium transport 
      in vivo: clinical implications.
PG  - 113-20
AB  - The effect of lithium (Li) and carbamazepine (CBZ) on erythrocyte lithium 
      transport in vivo was investigated in 28 patients with affective or 
      schizoaffective illness (14 given Li and 14 given CBZ). In 12 of them, Li or CBZ 
      were added to current psychotropic treatment. The activities of erythrocyte 
      lithium-sodium countertransport (LSC), lithium-potassium cotransport (LPC) and 
      passive lithium diffusion (PLD) were assayed before and after 28 days of 
      treatment. The administration of Li caused a significant decrease of LPC as well 
      as PLD activity. The administration of CBZ resulted in a significant increase of 
      the activity of LPC system. No systematic relationship was observed between Li or 
      CBZ-induced alterations in erythrocyte transport and changes in clinical state of 
      patients. The possible clinical implications of the dissimilar effect of Li and 
      CBZ on erythrocyte lithium transport are discussed.
FAU - Rybakowski, J
AU  - Rybakowski J
AD  - Department of Psychiatry, Medical Academy, Bydgoszcz, Poland.
FAU - Lehmann, W
AU  - Lehmann W
FAU - Matkowski, K
AU  - Matkowski K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Pol J Pharmacol Pharm
JT  - Polish journal of pharmacology and pharmacy
JID - 0366561
RN  - 0 (Antiporters)
RN  - 0 (Carrier Proteins)
RN  - 0 (sodium-lithium countertransporter)
RN  - 33CM23913M (Carbamazepine)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Antiporters
MH  - Biological Transport
MH  - Carbamazepine/*pharmacology
MH  - Carrier Proteins/blood
MH  - Diffusion
MH  - Erythrocytes/*metabolism
MH  - Female
MH  - Humans
MH  - Lithium/blood/*pharmacokinetics/pharmacology/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Psychotic Disorders/drug therapy
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PST - ppublish
SO  - Pol J Pharmacol Pharm. 1990 Mar-Apr;42(2):113-20.