PMID- 22744704
OWN - NLM
STAT- MEDLINE
DCOM- 20140226
LR  - 20220409
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 23
IP  - 8
DP  - 2013 Aug
TI  - Heat-evoked experimental pain induces long-term potentiation-like plasticity in 
      human primary motor cortex.
PG  - 1942-51
LID - 10.1093/cercor/bhs182 [doi]
AB  - We designed a new paired associative stimulation (PAS) protocol that combines 
      experimental pain evoked by laser stimuli and transcranial magnetic stimulation 
      (TMS) (Laser-PAS) to primary motor cortex (M1). We tested in healthy subjects 
      whether Laser-PAS elicits cortical plasticity as reflected by long-term changes 
      in motor-evoked potentials (MEPs) (after-effects). In separate experiments, we 
      examined numerous variables including changes induced by varying the 
      interstimulus intervals (ISIs) and Laser-PAS-induced changes in target and 
      non-target muscle MEPs. We measured MEPs after repetitive laser or TMS (rTMS) 
      pulses, and compared magnetic- and electric (TES)-induced MEPs. We tested MEPs 
      after applying Laser-PAS with laser pulses ipsilaterally to M1. Finally, we 
      studied subjects receiving an N-methyl-D-aspartate (NMDA) receptor antagonist 
      (memantine) or placebo (alpha-lipoic acid). During Laser-PAS at the 50 ms ISI MEPs 
      decreased, thereafter they increased for 60 min; other ISIs induced no 
      after-effects. The after-effects remained restricted to the target muscle. 
      Repetitive laser pulses and rTMS induced no after-effects. After Laser-PAS, 
      TMS-induced MEPs increased, whereas TES-induced MEPs did not. Laser-PAS with 
      laser pulses ipsilaterally to M1 left MEPs unchanged. Memantine, but not alpha-lipoic 
      acid, abolished the after-effects. In conclusion, Laser-PAS elicits 
      NMDA-dependent cortical plasticity and provides new insights into human 
      pain-motor integration.
FAU - Suppa, A
AU  - Suppa A
AD  - IRCCS Neuromed Institute, Sapienza University of Rome, 00185 Rome, Italy.
FAU - Biasiotta, A
AU  - Biasiotta A
FAU - Belvisi, D
AU  - Belvisi D
FAU - Marsili, L
AU  - Marsili L
FAU - La Cesa, S
AU  - La Cesa S
FAU - Truini, A
AU  - Truini A
FAU - Cruccu, G
AU  - Cruccu G
FAU - Berardelli, A
AU  - Berardelli A
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adult
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - *Hot Temperature
MH  - Humans
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Pain Perception/*physiology
MH  - Physical Stimulation/methods
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Transcranial Magnetic Stimulation/methods
MH  - Young Adult
OTO - NOTNLM
OT  - TMS
OT  - laser-evoked potentials
OT  - pain-motor integration
OT  - primary motor cortex
OT  - spike timing-dependent plasticity
EDAT- 2012/06/30 06:00
MHDA- 2014/02/27 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2014/02/27 06:00 [medline]
AID - bhs182 [pii]
AID - 10.1093/cercor/bhs182 [doi]
PST - ppublish
SO  - Cereb Cortex. 2013 Aug;23(8):1942-51. doi: 10.1093/cercor/bhs182. Epub 2012 Jun 
      28.