PMID- 22746314
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20191210
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 25
IP  - 12
DP  - 2012 Dec
TI  - Increased oxidant generation in the metabolism of hypoxanthine to uric acid and 
      endothelial dysfunction in early-onset and late-onset preeclamptic women.
PG  - 2662-6
LID - 10.3109/14767058.2012.705396 [doi]
AB  - OBJECTIVE: The purpose of this study was to evaluate the association of vascular 
      endothelial dysfunction with increased oxidant generation in the metabolism of 
      hypoxanthine to uric acid in early-onset compared to late-onset preeclampsia. 
      METHODS: We investigated 12 women with early-onset preeclampsia, 14 women with 
      late-onset preeclampsia, and 20 women with uncomplicated pregnancies. We measured 
      serum derivatives of reactive oxygen metabolites (d-ROMs) as a marker of oxygen 
      free radicals, serum biological antioxidant potential (BAP), hypoxanthine, uric 
      acid, uric acid clearance (CUA), and flow-mediated vasodilation (FMD) as a marker 
      of endothelial function in preeclamptic women. RESULTS: Concentration of d-ROMs 
      was significantly higher in both preeclamptic groups compared to the control 
      group. Plasma levels of uric acid were significantly elevated in both 
      preeclamptic groups compared to the control group. Plasma levels of hypoxanthine 
      were significantly higher in early-onset preeclamptic women compared to controls, 
      but not in late-onset preeclamptic women. CUA was significantly lower in 
      late-onset preeclamptic women compared to controls, but not in early-onset 
      preeclamptic women. The concentrations of hypoxanthine and uric acid correlated 
      positively with the concentration of d-ROMs in all pregnant women. FMD was 
      significantly lower in both preeclamptic groups compared with controls, but FMD 
      in the early-onset preeclamptic group was significantly lower than in the 
      late-onset preeclamptic group. CONCLUSIONS: We found that increased oxidant 
      generation during metabolism of hypoxanthine to uric acid may impair endothelial 
      function in early-onset preeclampsia.
FAU - Watanabe, Kazushi
AU  - Watanabe K
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Aichi, Japan. kw446433@yahoo.co.jp
FAU - Mori, Toshitaka
AU  - Mori T
FAU - Iwasaki, Ai
AU  - Iwasaki A
FAU - Kimura, Chiharu
AU  - Kimura C
FAU - Matsushita, Hiroshi
AU  - Matsushita H
FAU - Shinohara, Koichi
AU  - Shinohara K
FAU - Wakatsuki, Akihiko
AU  - Wakatsuki A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120718
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Oxidants)
RN  - 0 (Reactive Oxygen Species)
RN  - 268B43MJ25 (Uric Acid)
RN  - 2TN51YD919 (Hypoxanthine)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Case-Control Studies
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Hypoxanthine/blood/*metabolism
MH  - Oxidants/blood/*metabolism
MH  - Pre-Eclampsia/blood/epidemiology/*metabolism/*physiopathology
MH  - Pregnancy
MH  - Reactive Oxygen Species/blood/metabolism
MH  - Severity of Illness Index
MH  - Up-Regulation
MH  - Uric Acid/blood/*metabolism
MH  - Young Adult
EDAT- 2012/07/04 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.3109/14767058.2012.705396 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2012 Dec;25(12):2662-6. doi: 
      10.3109/14767058.2012.705396. Epub 2012 Jul 18.