PMID- 22746693
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20120810
IS  - 1557-8976 (Electronic)
IS  - 0882-8245 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Aug
TI  - Viral infection is associated with an increased proinflammatory response in 
      chronic obstructive pulmonary disease.
PG  - 249-53
LID - 10.1089/vim.2011.0095 [doi]
AB  - The development of new diagnostic methods based on molecular biology has led to 
      evidence of the important role of respiratory viruses in chronic obstructive 
      pulmonary disease (COPD) exacerbations. Cytokines and chemokines are recognized 
      as key actors in the pathogenesis of COPD. The objective of this study was to 
      evaluate the association between viral infection and host cytokine responses in 
      57 COPD patients hospitalized with an acute exacerbation. Seventeen cytokines 
      were profiled using a Luminex-Biorad multiplex assay in plasma samples collected 
      in the first 24 h following hospital admission. Stepwise linear regression 
      analysis was performed, taking into account the influence of seven potential 
      confounding factors in the results. Twenty-four out of 57 showed radiological 
      signs of community-acquired pneumonia (CAP) at hospital admission, 25 patients 
      required admission to the intensive care unit (ICU), 20 had a bacterial 
      infection, and 20 showed a detectable respiratory virus in pharyngeal swabs. 
      Regression analysis showed that viral infection correlated with higher levels of 
      interleukin-6 (IL-6) (log value of the coefficient of regression B, p=0.47, 
      0.044), and monocyte chemoattractant protein-1 (MCP-1) (p=0.43, 0.019), and 
      increased admission to the ICU. Viral infection also correlated with higher 
      levels of interferon-gamma (IFN-gamma) (p=0.70, 0.026), which, in turn, was inversely 
      associated with the severity of illness. Finally, viral infection was 
      independently associated with higher levels of tumor necrosis factor-alpha (TNF-alpha) 
      (p=0.40, 0.002). Thus our study demonstrates that in patients with COPD 
      exacerbations, viral infection is directly associated with higher systemic levels 
      of cytokines central to the development of the antiviral response, which are also 
      known to contribute to inflammation-mediated tissue damage. These results reveal 
      a potential specific role of viral infection in the pathogenesis of COPD 
      exacerbations.
FAU - Almansa, Raquel
AU  - Almansa R
AD  - Infection and Immunity Medical Investigation Unit, Hospital Clinico Universitario 
      de Valladolid-IECSCYL, Valladolid, Spain.
FAU - Socias, Lorenzo
AU  - Socias L
FAU - Andaluz-Ojeda, David
AU  - Andaluz-Ojeda D
FAU - Martin-Loeches, Ignacio
AU  - Martin-Loeches I
FAU - Bobillo, Felipe
AU  - Bobillo F
FAU - Blanco, Jesus
AU  - Blanco J
FAU - Rico, Lucia
AU  - Rico L
FAU - Berezo, Jose Angel
AU  - Berezo JA
FAU - Estella, Angel
AU  - Estella A
FAU - Sanchez-Garcia, Monica
AU  - Sanchez-Garcia M
FAU - San Jose, Alicia
AU  - San Jose A
FAU - Herrero, Agueda
AU  - Herrero A
FAU - Justel, Mar
AU  - Justel M
FAU - Roig, Vicente
AU  - Roig V
FAU - Del Olmo, Milagros
AU  - Del Olmo M
FAU - Rosich, Sara
AU  - Rosich S
FAU - Rodriguez, Irene
AU  - Rodriguez I
FAU - Disdier, Carlos
AU  - Disdier C
FAU - Eiros, Jose Maria
AU  - Eiros JM
FAU - Ortiz De Lejarazu, Raul
AU  - Ortiz De Lejarazu R
FAU - Bermejo-Martin, Jesus F
AU  - Bermejo-Martin JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120702
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Bacterial Infections/complications
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Inflammation/*complications
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*complications/immunology/physiopathology
MH  - Virus Diseases/*complications/*immunology
EDAT- 2012/07/04 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 10.1089/vim.2011.0095 [doi]
PST - ppublish
SO  - Viral Immunol. 2012 Aug;25(4):249-53. doi: 10.1089/vim.2011.0095. Epub 2012 Jul 
      2.