PMID- 22747479
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20120703
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 26 Suppl 24
DP  - 2012 Jul
TI  - A case of recurrent light chain deposition disease after living-related renal 
      transplantation - detailed process of the recurrence.
PG  - 64-9
LID - 10.1111/j.1399-0012.2012.01674.x [doi]
AB  - A 53-yr-old woman with end-stage renal disease was admitted for renal 
      transplantation (RTX). About a decade ago, she had presented with urinary 
      abnormalities. Monoclonal IgA lambda was detected. Renal biopsy showed nodular 
      glomerulosclerosis, and an immunohistochemical study for lambda was negative. 
      Fibrillary glomerulonephritis was suggested as the most likely diagnosis. RTX was 
      successfully performed, and graft function was stable for the first half year. 
      Graft biopsy was performed at one yr post-transplant. Glomeruli showed nodular 
      lesion similar to native kidney biopsy findings. Immunofluorescence microscopy 
      (IF) indicated strong lambda staining along the glomerular basement membrane, the 
      tubular basement membrane (TBM), and the peritubular capillary. The diagnosis of 
      recurrent light chain deposition disease (LCDD) was confirmed. A series of 
      biopsies are available to conduct studies on the recurrent process of LCDD. Light 
      microscopy showed no remarkable changes up to six months post-RTX. However, the 
      IF study revealed evident granular depositions of lambda along the TBM only at 
      the one-h biopsy. Typical IF staining pattern of lambda and EDD compatible with 
      LCDD were noted after six months post-transplant. This is the first case report 
      that elucidated the details of the recurrent process of LCDD at one yr after the 
      operation.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Horike, Keiji
AU  - Horike K
AD  - Kidney Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan. 
      keiji@nagoya2.jrc.or.jp
FAU - Takeda, Asami
AU  - Takeda A
FAU - Otsuka, Yasuhiro
AU  - Otsuka Y
FAU - Inaguma, Daijyo
AU  - Inaguma D
FAU - Goto, Norihiko
AU  - Goto N
FAU - Watarai, Yoshihiko
AU  - Watarai Y
FAU - Uchida, Kazuharu
AU  - Uchida K
FAU - Morozumi, Kunio
AU  - Morozumi K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Female
MH  - Humans
MH  - Immune Complex Diseases/*etiology/metabolism/pathology
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Kidney Transplantation/*adverse effects
MH  - *Living Donors
MH  - Microscopy, Fluorescence
MH  - Middle Aged
MH  - Paraproteinemias/*etiology/metabolism/pathology
MH  - Recurrence
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1399-0012.2012.01674.x [doi]
PST - ppublish
SO  - Clin Transplant. 2012 Jul;26 Suppl 24:64-9. doi: 
      10.1111/j.1399-0012.2012.01674.x.