PMID- 22748487
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20120703
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 7
DP  - 2012 Jul
TI  - Total plasma sulfide in congestive heart failure.
PG  - 541-8
LID - 10.1016/j.cardfail.2012.04.011 [doi]
AB  - BACKGROUND: Hydrogen sulfide (H(2)S) has emerged as a third gaseous transmitter 
      in mammals. In animal models of heart failure, treatment with an H(2)S donor can 
      protect the heart against adverse remodeling and attenuate cardiac dysfunction. 
      The aim was to determine total plasma sulfide in patients with congestive heart 
      failure. METHODS AND RESULTS: Total plasma sulfide was determined in 57 patients 
      on admission to an outpatient clinic or cardiology department. Total plasma 
      sulfide concentrations in these patients was lower compared with a control group 
      (5.32 [2.22, 8.00] muM vs. 8.5 [6.00, 14.00] muM; P = .05). Total plasma sulfide 
      decreased significantly across the New York Heart Association (NYHA) functional 
      classes (II, 5.84 [4.33, 8.00] muM vs. III, 4.67 [4.00, 7.17] muM vs. IV, 2.67 
      [2.22, 4.31] muM; P = .001). The total plasma sulfide negatively correlated with 
      pro-BNP (R(2) cubic, 0.692; P = .001) and pulmonary artery systolic pressure 
      (R(2) cubic, 0.569; P = .001). The receiver operating characteristic analysis of 
      the area under the curve for total plasma sulfide as a predictor of mortality was 
      0.904 (95% CI, 0.822-0.987; P = .001), and of rehospitalization was 0.779 (95% 
      CI, 0.650-0.908; P = .001). Total plasma sulfide was a univariate predictor of 
      mortality (odds ratio, 0.245; 95% CI, 0.108-0.555; P = .001). CONCLUSION: Total 
      plasma sulfide is negatively related to severity of congestive heart failure: it 
      is lowest in NYHA Class IV and in patients with high pro-BNP and high pulmonary 
      artery pressure. Low total plasma sulfide predicts a higher mortality rate.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kovacic, Dragan
AU  - Kovacic D
AD  - Department of Cardiology, Celje General and Teaching Hospital, Celje, Slovenia.
FAU - Glavnik, Nina
AU  - Glavnik N
FAU - Marinsek, Matej
AU  - Marinsek M
FAU - Zagozen, Petra
AU  - Zagozen P
FAU - Rovan, Ksenija
AU  - Rovan K
FAU - Goslar, Tomaz
AU  - Goslar T
FAU - Mars, Tomaz
AU  - Mars T
FAU - Podbregar, Matej
AU  - Podbregar M
LA  - eng
PT  - Journal Article
DEP - 20120530
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Peptide Fragments)
RN  - 0 (Sulfides)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Blood Pressure/physiology
MH  - Case-Control Studies
MH  - Female
MH  - Heart Failure/*blood/classification/*mortality
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/blood
MH  - Patient Readmission
MH  - Peptide Fragments/blood
MH  - Pulmonary Artery/physiology
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
MH  - Sulfides/*blood
MH  - Systole/physiology
EDAT- 2012/07/04 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/10/19 00:00 [received]
PHST- 2012/04/24 00:00 [revised]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - S1071-9164(12)00150-9 [pii]
AID - 10.1016/j.cardfail.2012.04.011 [doi]
PST - ppublish
SO  - J Card Fail. 2012 Jul;18(7):541-8. doi: 10.1016/j.cardfail.2012.04.011. Epub 2012 
      May 30.