PMID- 22748497
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20181202
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 167
IP  - 6
DP  - 2013 Sep 10
TI  - Resveratrol induces nuclear factor-kappaB activity in human cardiac cells.
PG  - 2507-16
LID - S0167-5273(12)00781-4 [pii]
LID - 10.1016/j.ijcard.2012.06.006 [doi]
AB  - BACKGROUND: Resveratrol is a grape polyphenol that prevents cardiac hypertrophy 
      and protects the heart from ischemic injury, metabolic dysregulation, and 
      inflammatory processes in several murine models. METHODS AND RESULTS: The aim of 
      this study was to investigate the effects of resveratrol on the inflammatory 
      processes in human cardiac AC16 cells in order to gain a better understanding of 
      its cardioprotective mechanisms in the human heart. Resveratrol induced the 
      DNA-binding activity of the pro-inflammatory transcription factor NF-kappaB in AC16 
      cells, and exacerbated the increase caused by tumor necrosis factor-alpha (TNF-alpha). In 
      accordance with this, resveratrol increased the expression of the 
      pro-inflammatory genes ICAM-1 (intercellular adhesion molecule-1) and TNF-alpha. In 
      contrast, resveratrol decreased the expression of pro-inflammatory genes IL-6 
      (interleukin-6) and MCP-1 (monocyte chemoattractant protein-1). Likewise, 
      resveratrol also induced inflammation in rat neonatal cardiomyocytes, and in the 
      heart of mice fed a standard chow diet supplemented with resveratrol (1g/kg diet) 
      for four months. Western-blot analyses revealed that NF-kappaB p65 subunit levels 
      were upregulated in an IkappaB-dependent manner in the nuclei of resveratrol-treated 
      human cardiac cells. Finally, resveratrol activated the signal transducer and 
      activator of transcription 3 (STAT3) signaling and induced the expression of its 
      anti-apoptotic downstream effector Bcl-xL, both involved in the cardioprotective 
      survival activating factor enhancement (SAFE) pathway. CONCLUSIONS: Resveratrol 
      enhanced NF-kappaB activity in human and murine cardiac cells, in a process that 
      coincided with the activation of STAT3 and anti-apoptotic downstream effectors. 
      Therefore, activation of the SAFE pathway by resveratrol might be involved in the 
      cardioprotective effects of this compound.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Palomer, Xavier
AU  - Palomer X
AD  - Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, 
      University of Barcelona and IBUB, Institut de Biomedicina de la Universitat de 
      Barcelona, 643 Diagonal, E-08028 Barcelona, Spain.
FAU - Capdevila-Busquets, Eva
AU  - Capdevila-Busquets E
FAU - Alvarez-Guardia, David
AU  - Alvarez-Guardia D
FAU - Barroso, Emma
AU  - Barroso E
FAU - Pallas, Merce
AU  - Pallas M
FAU - Camins, Antoni
AU  - Camins A
FAU - Davidson, Mercy M
AU  - Davidson MM
FAU - Planavila, Ana
AU  - Planavila A
FAU - Villarroya, Francesc
AU  - Villarroya F
FAU - Vazquez-Carrera, Manuel
AU  - Vazquez-Carrera M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120627
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (NF-kappa B)
RN  - 0 (Stilbenes)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Humans
MH  - Male
MH  - Mice
MH  - Myocytes, Cardiac/*drug effects/*metabolism
MH  - NF-kappa B/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Resveratrol
MH  - Stilbenes/*pharmacology
OTO - NOTNLM
OT  - AMP-activated protein kinase
OT  - AMPK
OT  - Cardiovascular disease
OT  - EMSA
OT  - HAT
OT  - HDAC
OT  - Heart
OT  - ICAM-1
OT  - IKKalpha
OT  - IL-6
OT  - Inflammation
OT  - IkappaBalpha kinase
OT  - MCP-1
OT  - NF-kappaB
OT  - Resveratrol
OT  - SAFE
OT  - SOCS
OT  - STAT3
OT  - TNF-alpha
OT  - electrophoretic mobility shift assay
OT  - histone acetyltransferase
OT  - histone deacetylase
OT  - intercellular adhesion molecule-1
OT  - interleukin 6
OT  - monocyte chemoattractant protein-1
OT  - nuclear factor-kappaB
OT  - signal transducer and activator of transcription 3
OT  - suppressor of cytokine signaling
OT  - survival activating factor enhancement
OT  - tumor necrosis factor-alpha
EDAT- 2012/07/04 06:00
MHDA- 2014/04/23 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/03/20 00:00 [received]
PHST- 2012/06/01 00:00 [revised]
PHST- 2012/06/08 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0167-5273(12)00781-4 [pii]
AID - 10.1016/j.ijcard.2012.06.006 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Sep 10;167(6):2507-16. doi: 10.1016/j.ijcard.2012.06.006. 
      Epub 2012 Jun 27.