PMID- 2274889
OWN - NLM
STAT- MEDLINE
DCOM- 19910228
LR  - 20121115
IS  - 0040-3709 (Print)
IS  - 0040-3709 (Linking)
VI  - 42
IP  - 3
DP  - 1990 Sep
TI  - Developmental toxicity of temafloxacin hydrochloride in the long-tailed macaque 
      (Macaca fascicularis).
PG  - 233-42
AB  - The potential developmental toxicity of temafloxacin hydrochloride was studied in 
      the long-tailed macaque (Macaca fascicularis). Ten animals in each of the three 
      drug-treated groups (25, 50, and 100 mg/kg) were administered temafloxacin via 
      nasogastric intubation during gestational days (GD) 20-50. A control group of ten 
      animals received vehicle only. The dams were monitored daily for adverse physical 
      signs and maternal blood samples were collected for analyses of serum 
      progesterone (P), 17 beta-estradiol (E2), and chorionic gonadotropin (CG). In 
      addition, the conceptus was monitored periodically by ultrasound during gestation 
      to confirm growth and viability. Increased maternal toxicity (weight loss, 
      anorexia, emesis) and embryolethality were observed at 100 mg/kg, and a 
      no-observable-adverse-effect-level (NOAEL) of 50 mg/kg was established. The 
      incidence of prenatal mortality was as follows: Control = 1/10 (10%); 25 mg/kg = 
      1/10 (10%); 50 mg/kg = 2/10 (20%); and 100 mg/kg = 5/10 (50%). Analysis of P, E2, 
      and CG indicated no significant effect of treatment. In addition, no significant 
      differences were observed in embryonic/fetal growth and development when compared 
      to historical controls. No gross structural changes were observed in fetuses 
      exposed to 50 or 100 mg/kg, although one fetus exposed to 25 mg/kg exhibited 
      microphthalmia. This anomaly was considered spontaneous and, therefore, unrelated 
      to treatment.
FAU - Tarantal, A F
AU  - Tarantal AF
AD  - California Primate Research Center, University of California, Davis 95617-8542.
FAU - Lehrer, S B
AU  - Lehrer SB
FAU - Lasley, B L
AU  - Lasley BL
FAU - Hendrickx, A G
AU  - Hendrickx AG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teratology
JT  - Teratology
JID - 0153257
RN  - 0 (4-Quinolones)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Quinolones)
RN  - 0 (Teratogens)
RN  - 1WZ12GTT67 (temafloxacin)
SB  - IM
MH  - 4-Quinolones
MH  - Animals
MH  - Anti-Infective Agents/*toxicity
MH  - Appetite/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - *Fluoroquinolones
MH  - Macaca fascicularis
MH  - Pregnancy
MH  - *Quinolones
MH  - *Teratogens
MH  - Vomiting/chemically induced
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - 10.1002/tera.1420420307 [doi]
PST - ppublish
SO  - Teratology. 1990 Sep;42(3):233-42. doi: 10.1002/tera.1420420307.