PMID- 22749234
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20221207
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 38
IP  - 5
DP  - 2012 Nov
TI  - Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARgamma, SLC30A8 
      and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs.
PG  - 444-9
LID - S1262-3636(12)00089-4 [pii]
LID - 10.1016/j.diabet.2012.05.002 [doi]
AB  - BACKGROUND: While several type 2 diabetes mellitus (T2DM) susceptibility loci 
      identified through genome-wide association studies (GWAS) have been replicated in 
      many populations, their association in Arabs has not been reported. For this 
      reason, the present study looked at the contribution of ENNP1 (rs1044498), 
      IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARgamma (rs1801282), 
      SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese 
      and Tunisian Arabs. METHODS: Study subjects (case/controls) were Lebanese 
      (751/918) and Tunisians (1470/838). Genotyping was carried out by the allelic 
      discrimination method. RESULTS: In Lebanese and Tunisians, neither ENNP1 nor 
      MLXIPL was associated with T2DM, whereas TCF7L2 was significantly associated with 
      an increased risk of T2DM in both the Lebanese [P < 0.001; OR (95% CI): 1.38 
      (1.20-1.59)] and Tunisians [P < 0.001; OR (95% CI): 1.36 (1.18-1.56)]. 
      Differential associations of IGF2BP2, KCNJ11, PPARgamma and SLC30A8 with T2DM were 
      noted in the two populations. IGF2BP2 [P = 1.3 x 10(-5); OR (95% CI): 1.66 
      (1.42-1.94)] and PPARgamma [P = 0.005; OR (95% CI): 1.41 (1.10-1.80)] were associated 
      with T2DM in the Lebanese, but not Tunisians, while KCNJ11 [P = 8.0 x 10(-4); OR 
      (95% CI): 1.27 (1.09-1.47)] and SLC30A8 [P = 1.6 x 10(-5); OR (95% CI): 1.37 
      (1.15-1.62)] were associated with T2DM in the Tunisians, but not Lebanese, after 
      adjusting for gender and body mass index. CONCLUSION: T2DM susceptibility loci 
      SNPs identified through GWAS showed differential associations with T2DM in two 
      Arab populations, thus further confirming the ethnic contributions of these 
      variants to T2DM susceptibility.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Mtiraoui, N
AU  - Mtiraoui N
AD  - Research Unit of Biology and Genetics of Hematological and Autoimmune diseases, 
      Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
FAU - Turki, A
AU  - Turki A
FAU - Nemr, R
AU  - Nemr R
FAU - Echtay, A
AU  - Echtay A
FAU - Izzidi, I
AU  - Izzidi I
FAU - Al-Zaben, G S
AU  - Al-Zaben GS
FAU - Irani-Hakime, N
AU  - Irani-Hakime N
FAU - Keleshian, S H
AU  - Keleshian SH
FAU - Mahjoub, T
AU  - Mahjoub T
FAU - Almawi, W Y
AU  - Almawi WY
LA  - eng
PT  - Journal Article
DEP - 20120627
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (Cation Transport Proteins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (IGF2BP2 protein, human)
RN  - 0 (Kir6.2 channel)
RN  - 0 (MLXIPL protein, human)
RN  - 0 (PPAR gamma)
RN  - 0 (Potassium Channels, Inwardly Rectifying)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SLC30A1 protein, human)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
RN  - 0 (hemoglobin A1c protein, human)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.1 (ectonucleotide pyrophosphatase phosphodiesterase 1)
RN  - EC 3.6.1.- (Pyrophosphatases)
SB  - IM
MH  - Arabs/*genetics
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics
MH  - Body Mass Index
MH  - Cation Transport Proteins/genetics
MH  - Diabetes Mellitus, Type 2/epidemiology/ethnology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Lebanon/epidemiology/ethnology
MH  - Male
MH  - Middle Aged
MH  - PPAR gamma/genetics
MH  - Phosphoric Diester Hydrolases/genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Potassium Channels, Inwardly Rectifying/genetics
MH  - Pyrophosphatases/genetics
MH  - RNA-Binding Proteins/genetics
MH  - Transcription Factor 7-Like 2 Protein/genetics
MH  - Tunisia/epidemiology/ethnology
EDAT- 2012/07/04 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/05/07 00:00 [revised]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - S1262-3636(12)00089-4 [pii]
AID - 10.1016/j.diabet.2012.05.002 [doi]
PST - ppublish
SO  - Diabetes Metab. 2012 Nov;38(5):444-9. doi: 10.1016/j.diabet.2012.05.002. Epub 
      2012 Jun 27.