PMID- 22749354
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20231213
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 36
IP  - 6
DP  - 2012 Jun 29
TI  - NK cell-derived interferon-gamma orchestrates cellular dynamics and the 
      differentiation of monocytes into dendritic cells at the site of infection.
PG  - 1047-59
LID - 10.1016/j.immuni.2012.03.026 [doi]
AB  - Dendritic cells (DCs), monocytes, and/or macrophages initiate host-protective 
      immune responses to intracellular pathogens in part through interleukin-12 
      (IL-12) production, although the relative contribution of tissue resident versus 
      recruited cells has been unclear. Here, we showed that after intraperitoneal 
      infection with Toxoplasma gondii cysts, resident mononuclear phagocytes are 
      replaced by circulating monocytes that differentiate in situ into inflammatory 
      DCs (moDCs) and F4/80(+) macrophages. Importantly, NK cell-derived interferon-gamma 
      (IFN-gamma) was required for both the loss of resident mononuclear phagocytes and the 
      local differentiation of monocytes into macrophages and moDCs. This newly 
      generated moDC population and not the resident DCs (or macrophages) served as the 
      major source of IL-12 at the site of infection. Thus, NK cell-derived IFN-gamma is 
      important in both regulating inflammatory cell dynamics and in driving the local 
      differentiation of monocytes into the cells required for initiating the immune 
      response to an important intracellular pathogen.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Goldszmid, Romina S
AU  - Goldszmid RS
AD  - Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center 
      for Cancer Research, National Cancer Institute, National Institutes of Health, 
      Frederick, MD 21702, USA. rgoldszmid@mail.nih.gov
FAU - Caspar, Pat
AU  - Caspar P
FAU - Rivollier, Aymeric
AU  - Rivollier A
FAU - White, Sandy
AU  - White S
FAU - Dzutsev, Amiran
AU  - Dzutsev A
FAU - Hieny, Sara
AU  - Hieny S
FAU - Kelsall, Brian
AU  - Kelsall B
FAU - Trinchieri, Giorgio
AU  - Trinchieri G
FAU - Sher, Alan
AU  - Sher A
LA  - eng
GR  - Z99 CA999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Antigens, Ly)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 0 (Ly-6C antigen, mouse)
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Receptors, Interferon)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Immunity. 2012 Jun 29;36(6):904-6. PMID: 22749350
MH  - Adoptive Transfer
MH  - Animals
MH  - Antigens, Ly/analysis
MH  - Cell Differentiation
MH  - Chemotaxis, Leukocyte
MH  - Dendritic Cells/*immunology/pathology/transplantation
MH  - Genes, Reporter
MH  - Interferon-gamma/*physiology
MH  - Interleukin-12 Subunit p40/biosynthesis/genetics
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Macrophages, Peritoneal/immunology/transplantation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Monocytes/chemistry/*immunology/pathology/transplantation
MH  - Myeloid Differentiation Factor 88/physiology
MH  - Neutrophils/immunology
MH  - Peritonitis/immunology/parasitology
MH  - Phagocytes/classification/immunology/pathology
MH  - Receptors, Interferon/deficiency/physiology
MH  - Recombinant Fusion Proteins/biosynthesis/genetics
MH  - Specific Pathogen-Free Organisms
MH  - T-Lymphocyte Subsets/immunology
MH  - Toxoplasmosis, Animal/immunology
MH  - Interferon gamma Receptor
PMC - PMC3412151
MID - NIHMS386732
COIS- The authors have no conflicting financial interests.
EDAT- 2012/07/04 06:00
MHDA- 2012/09/14 06:00
PMCR- 2013/06/29
CRDT- 2012/07/04 06:00
PHST- 2011/09/21 00:00 [received]
PHST- 2012/02/04 00:00 [revised]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
PHST- 2013/06/29 00:00 [pmc-release]
AID - S1074-7613(12)00242-7 [pii]
AID - 10.1016/j.immuni.2012.03.026 [doi]
PST - ppublish
SO  - Immunity. 2012 Jun 29;36(6):1047-59. doi: 10.1016/j.immuni.2012.03.026.