PMID- 22749404
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20220331
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 56
IP  - 1
DP  - 2013 Jan-Feb
TI  - Physical exercise modulates peripheral levels of brain-derived neurotrophic 
      factor (BDNF): a systematic review of experimental studies in the elderly.
PG  - 10-5
LID - S0167-4943(12)00127-6 [pii]
LID - 10.1016/j.archger.2012.06.003 [doi]
AB  - The objective of this study was to conduct a systematic review of studies that 
      analyzed the effect of physical exercise on the peripheral levels of BDNF in 
      elderly individuals. METHOD: We conducted a search in PsycINFO, Biological 
      Abstracts, Pubmed, Web of Science, and Science Direct from 1990 to 2011, using 
      the following keywords: "physical exercise", "physical activity", "physical 
      therapy", "training", "BDNF", "neuroplasticity", "neurotrophins", 
      "neuroplasticity proteins", "aged", "older", "elderly". The articles were 
      considered for inclusion in the review if they were studies with elderly, 
      assessed peripheral (serum and/or plasma) BDNF and evaluated an acute exercise or 
      chronic exercise (training). RESULTS: Five randomized controlled trial and one 
      randomized non-controlled trial studies were analyzed. Five out of six studies 
      reported a significantly higher BDNF response to aerobic acute exercise and to 
      aerobic or strength training program in healthy elderly and elderly with 
      different pathologies. CONCLUSION: It was not possible to establish a 
      recommendation protocol for the type and intensity of physical exercise required 
      to produce an increase in levels BDNF. However, physical exercise, particularly, 
      moderate-intensity exercises seem to be more effective to promote increase the 
      peripheral levels of BDNF in the elderly.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Coelho, Flavia Gomes de Melo
AU  - Coelho FG
AD  - Institute of Biosciences, UNESP, Univ. Estadual Paulista, Physical Activity and 
      Aging Lab (LAFE), Rio Claro, SP, Brazil. flaviaeduca@yahoo.com.br
FAU - Gobbi, Sebastiao
AU  - Gobbi S
FAU - Andreatto, Carla Andreza Almeida
AU  - Andreatto CA
FAU - Corazza, Danilla Icassati
AU  - Corazza DI
FAU - Pedroso, Renata Valle
AU  - Pedroso RV
FAU - Santos-Galduroz, Ruth Ferreira
AU  - Santos-Galduroz RF
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20120629
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood/physiology
MH  - Exercise/*physiology
MH  - Humans
EDAT- 2012/07/04 06:00
MHDA- 2013/05/04 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/03/04 00:00 [received]
PHST- 2012/05/31 00:00 [revised]
PHST- 2012/06/02 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - S0167-4943(12)00127-6 [pii]
AID - 10.1016/j.archger.2012.06.003 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2013 Jan-Feb;56(1):10-5. doi: 
      10.1016/j.archger.2012.06.003. Epub 2012 Jun 29.