PMID- 22749920 OWN - NLM STAT- MEDLINE DCOM- 20130103 LR - 20141021 IS - 1532-2688 (Electronic) IS - 1059-1311 (Linking) VI - 21 IP - 8 DP - 2012 Oct TI - Safety of video-EEG monitoring and surgical outcome in patients with mesial temporal sclerosis and psychosis of epilepsy. PG - 583-7 LID - 10.1016/j.seizure.2012.06.002 [doi] AB - PURPOSE: Cortico-amygdalohippocampectomy (CAH) has become an important treatment option for patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS); it has resulted in a 60-70% seizure remission rate and significant quality of life (QOL) improvements. Video-electroencephalography (VEEG) monitoring has been widely used in epilepsy centers for pre-surgical evaluation. A major concern in epilepsy surgery is whether to consider CAH treatment in patients with psychosis of epilepsy (POE). This study analyzed the safety and adverse events (AEs) of VEEG monitoring and the post-surgical outcomes of patients with refractory TLE-MTS and POE who underwent CAH. METHOD: Clinical, sociodemographic and VEEG data from 18 patients with TLE-MTS and POE were analyzed. Psychiatric evaluations were performed using DSM-IV and ILAE criteria. The seizure outcome was evaluated using Engel's criteria. RESULTS: Two patients (11.2%) presented AEs that did not result in increased lengths of hospitalization. Of the 10 patients (55.5%) who underwent CAH, 6 (60%) became free of disabling seizures (Engel I). The psychiatric and QOL evaluations revealed improvements of psychotic symptoms (p=0.01) and in Physical Health (p=0.01) following surgery. CONCLUSION: These data reinforce that VEEG monitoring is a safe method to evaluate patients with refractory TLE-MTS and POE in epilepsy centers. CI - Copyright (c) 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - da Conceicao, Priscila Oliveira AU - da Conceicao PO AD - Department of Neurology and Neurosurgery, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil. FAU - de Araujo Filho, Gerardo Maria AU - de Araujo Filho GM FAU - Mazetto, Lenon AU - Mazetto L FAU - Alonso, Neide Barreira AU - Alonso NB FAU - Yacubian, Elza Marcia Targas AU - Yacubian EM LA - eng PT - Journal Article DEP - 20120629 PL - England TA - Seizure JT - Seizure JID - 9306979 SB - IM MH - Adult MH - Aged MH - *Anterior Temporal Lobectomy/adverse effects/methods MH - *Electroencephalography MH - Epilepsy, Temporal Lobe/complications/*psychology/*surgery MH - Female MH - Humans MH - Male MH - Middle Aged MH - Monitoring, Physiologic MH - Postoperative Complications/epidemiology/etiology MH - Preoperative Care/*methods MH - Psychotic Disorders/*etiology/surgery MH - Sclerosis MH - Temporal Lobe/pathology/surgery MH - Treatment Outcome MH - Video Recording EDAT- 2012/07/04 06:00 MHDA- 2013/01/04 06:00 CRDT- 2012/07/04 06:00 PHST- 2012/04/29 00:00 [received] PHST- 2012/06/04 00:00 [revised] PHST- 2012/06/05 00:00 [accepted] PHST- 2012/07/04 06:00 [entrez] PHST- 2012/07/04 06:00 [pubmed] PHST- 2013/01/04 06:00 [medline] AID - S1059-1311(12)00148-3 [pii] AID - 10.1016/j.seizure.2012.06.002 [doi] PST - ppublish SO - Seizure. 2012 Oct;21(8):583-7. doi: 10.1016/j.seizure.2012.06.002. Epub 2012 Jun 29.