PMID- 22750488
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20161125
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 34
IP  - 3
DP  - 2012 Nov
TI  - Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro.
PG  - 443-50
LID - 10.1016/j.reprotox.2012.06.008 [doi]
AB  - This study investigated the effects of antipsychotic drugs on heart function of 
      gestational day (GD) 13 rat embryos in vitro since they all block the I(Kr)/hERG 
      potassium ion channel in addition to their main pharmacological effect on 
      neurotransmitters. The results showed that all the tested antipsychotic drugs 
      caused bradycardia of the rat embryonic heart in a concentration-dependent 
      manner. However, with the possible exception of haloperidol the tested drugs did 
      not cause arrhythmias typically seen with the highly selective I(Kr)/hERG 
      blocking drug dofetilide. For six of the eight drugs tested the effects on the 
      embryonic rat heart were only seen at free drug concentrations that were much 
      greater than those likely to occur in pregnant women taking antipsychotic 
      medication. However, the safety margins for haloperidol and quetiapine were 
      lower.
CI  - Crown Copyright (c) 2012. Published by Elsevier Inc. All rights reserved.
FAU - Gunnstrom, M
AU  - Gunnstrom M
AD  - Department of Anatomy and Histology, Sydney Medical School, University of Sydney, 
      Sydney, Australia.
FAU - Ababneh, D
AU  - Ababneh D
FAU - Webster, W S
AU  - Webster WS
FAU - Oakes, D
AU  - Oakes D
FAU - Ritchie, H
AU  - Ritchie H
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Antipsychotic Agents)
RN  - 0 (ERG1 Potassium Channel)
RN  - 0 (Ether-A-Go-Go Potassium Channels)
RN  - 0 (NAV1.5 Voltage-Gated Sodium Channel)
RN  - 0 (Potassium Channel Blockers)
RN  - 0 (Scn5a protein, rat)
RN  - 0 (Sodium Channel Blockers)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*adverse effects
MH  - Bradycardia/*chemically induced/physiopathology
MH  - ERG1 Potassium Channel
MH  - Embryo, Mammalian/*drug effects/physiology/physiopathology
MH  - Ether-A-Go-Go Potassium Channels/antagonists & inhibitors/physiology
MH  - Female
MH  - Heart Rate/drug effects
MH  - NAV1.5 Voltage-Gated Sodium Channel/physiology
MH  - Potassium Channel Blockers/*adverse effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Channel Blockers/*adverse effects
EDAT- 2012/07/04 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/02/20 00:00 [received]
PHST- 2012/05/30 00:00 [revised]
PHST- 2012/06/15 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0890-6238(12)00234-1 [pii]
AID - 10.1016/j.reprotox.2012.06.008 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2012 Nov;34(3):443-50. doi: 10.1016/j.reprotox.2012.06.008. Epub 
      2012 Jun 28.