PMID- 22750489
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20121106
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 27
IP  - 2-3
DP  - 2012 Oct
TI  - Impact of HLA-G 14-bp polymorphism on acute rejection and cytomegalovirus 
      infection in kidney transplant recipients from northwestern China.
PG  - 69-74
LID - S0966-3274(12)00048-2 [pii]
LID - 10.1016/j.trim.2012.06.008 [doi]
AB  - Human leukocyte antigen (HLA)-G plays an important role in promoting transplant 
      tolerance and helping human cytomegalovirus (CMV) to subvert host defenses. 
      Strong evidence suggests that HLA-G 14-bp insertion/deletion polymorphism 
      influences the stability of HLA-G mRNAs and levels of protein expression. We 
      hypothesized that HLA-G 14-bp polymorphism of recipients has an influence on the 
      risk of acute rejection (AR) and CMV infection. We investigated the impact of 
      HLA-G 14-bp polymorphism on a total of 363 unrelated Chinese Han individuals who 
      included 42 kidney transplant recipients with AR, 43 recipients with CMV 
      infection, 102 recipients with stable allograft function (STA), and 176 healthy 
      controls (HC). No statistically significant difference was found between all 
      kidney transplant patients and HC (P=0.149). But, our data showed an increased 
      frequency of homozygous genotype +14/+14 bp (P(c)=0.004) and allele +14 bp 
      (P(c)=0.002) in patients with AR when compared with STA, with the odds ratio of 
      3.17 and 2.28, respectively. Moreover, we found that the frequency of the -14/-14 
      bp genotype (P(c)=0.008) and the -14 bp allele (P(c)=0.016) was increased in 
      patients with CMV infection when compared with STA, with the OR of 2.66 and 1.96, 
      respectively. Multivariate analysis further demonstrated that HLA-G homozygous 
      +14 bp and -14 bp genotypes were an independent risk factor for allograft 
      rejection and CMV infection, respectively. In conclusion, this study identified 
      an important genetic risk factor for acute allograft rejection, and it was the 
      first to show a significant correlation between HLA-G 14-bp polymorphism and CMV 
      infection after kidney transplantation from northwestern China.
CI  - Crown Copyright (c) 2012. Published by Elsevier B.V. All rights reserved.
FAU - Jin, Zhan-Kui
AU  - Jin ZK
AD  - Department of Kidney Transplantation, Hospital of Nephropathy, First Affiliated 
      Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
FAU - Xu, Cui-Xiang
AU  - Xu CX
FAU - Tian, Pu-Xun
AU  - Tian PX
FAU - Xue, Wu-Jun
AU  - Xue WJ
FAU - Ding, Xiao-Ming
AU  - Ding XM
FAU - Zheng, Jin
AU  - Zheng J
FAU - Ding, Chen-Guang
AU  - Ding CG
FAU - Ge, Guan-Qun
AU  - Ge GQ
FAU - Mao, Tian-Ci
AU  - Mao TC
FAU - Lin, Yuan
AU  - Lin Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120630
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - China
MH  - Cytomegalovirus/*immunology
MH  - Cytomegalovirus Infections/*genetics/immunology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graft Rejection/etiology/*genetics/immunology
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Polymorphism, Genetic
MH  - Postoperative Complications/*genetics/immunology
MH  - Risk
EDAT- 2012/07/04 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/05/01 00:00 [received]
PHST- 2012/06/21 00:00 [revised]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S0966-3274(12)00048-2 [pii]
AID - 10.1016/j.trim.2012.06.008 [doi]
PST - ppublish
SO  - Transpl Immunol. 2012 Oct;27(2-3):69-74. doi: 10.1016/j.trim.2012.06.008. Epub 
      2012 Jun 30.