PMID- 22750524
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20130702
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 57
DP  - 2013 Sep
TI  - Exercise counteracts declining hippocampal function in aging and Alzheimer's 
      disease.
PG  - 47-55
LID - S0969-9961(12)00226-4 [pii]
LID - 10.1016/j.nbd.2012.06.011 [doi]
AB  - Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as 
      the most common type of dementia (Thies and Bleiler, 2011), yet effective 
      pharmacological treatments have not been identified. Substantial evidence 
      indicates that physical activity enhances learning and memory for people of all 
      ages, including individuals that suffer from cognitive impairment. The mechanisms 
      that underlie these benefits have been explored using animal models, including 
      transgenic models of AD. Accumulating research shows that physical activity 
      reinstates hippocampal function by enhancing the expression of brain-derived 
      neurotrophic factor (BDNF) and other growth factors that promote neurogenesis, 
      angiogenesis, and synaptic plasticity. In addition, several studies have found 
      that physical activity counteracts age- and AD-associated declines in 
      mitochondrial and immune system function. A growing body of evidence also 
      suggests that exercise interventions hold the potential to reduce the 
      pathological features associated with AD. Taken together, animal and human 
      studies indicate that exercise provides a powerful stimulus that can countervail 
      the molecular changes that underlie the progressive loss of hippocampal function 
      in advanced age and AD.
CI  - 2012 Published by Elsevier Inc
FAU - Intlekofer, Karlie A
AU  - Intlekofer KA
AD  - Institute for Memory Impairments and Neurological Disorders, University of 
      California Irvine, Irvine CA 92697-4260, USA.
FAU - Cotman, Carl W
AU  - Cotman CW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120630
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
SB  - IM
MH  - Aging/*physiology
MH  - Alzheimer Disease/immunology/*physiopathology/*therapy
MH  - Animals
MH  - Disease Models, Animal
MH  - Exercise Therapy
MH  - Hippocampus/physiology/*physiopathology
MH  - Humans
MH  - Immune System/immunology
MH  - Memory/*physiology
MH  - Mice
EDAT- 2012/07/04 06:00
MHDA- 2014/01/01 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/02/13 00:00 [received]
PHST- 2012/05/25 00:00 [revised]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - S0969-9961(12)00226-4 [pii]
AID - 10.1016/j.nbd.2012.06.011 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2013 Sep;57:47-55. doi: 10.1016/j.nbd.2012.06.011. Epub 2012 Jun 
      30.