PMID- 22750764
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 0975-4466 (Electronic)
IS  - 0256-4947 (Print)
IS  - 0256-4947 (Linking)
VI  - 32
IP  - 6
DP  - 2012 Jul 1
TI  - Intravenous immunoglobulin-associated renal failure in a patient with 
      post-transfusion purpura.
PG  - 1-2
AB  - Intravenous immunoglobulin (IVIG), initially developed for immunodeficiency 
      disorders, has now been used for multiple autoimmune diseases and infections. 
      These are generally well tolerated, with few adverse effects. Acute kidney injury 
      has been described in very rare instances. We report an interesting case of a 
      59-year-old African American male with a pertinent history of diabetes mellitus, 
      hypertension, endocarditis, and peripheral vascular disease, who was diagnosed 
      with post-transfusion purpura. He was then treated with IVIG and subsequently 
      developed an acute worsening of renal function in a time span of 3 days. The 
      etiology remained elusive even after an extensive workup. Renal biopsy was done 
      finally, which showed findings suggestive of osmotic nephropathy that was traced 
      to the sucrose used as a stabilizing agent in the IVIG. In light of the 
      increasing use of IVIG, it is therefore highly recommended that clinicians are 
      well aware of this side effect of IVIG.
FAU - Cherian, Sujith V
AU  - Cherian SV
AD  - Sujith V. Cherian, 50 Presidential Plaza, Apt 2106, Syracuse, New York, USA 
      13202, T: 1 818 854 5737, F: 1 315 464 44 84 sujithvcherian@gmail.com.
FAU - Das, Subhraleena
AU  - Das S
FAU - Garcha, Amarinder S
AU  - Garcha AS
FAU - Manocha, Divey
AU  - Manocha D
FAU - Kosaraju, Nitish
AU  - Kosaraju N
LA  - eng
PT  - Journal Article
DEP - 20120701
PL  - Saudi Arabia
TA  - Ann Saudi Med
JT  - Annals of Saudi medicine
JID - 8507355
PMC - PMC6081101
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:00
PMCR- 2012/11/01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - asm-6-646 [pii]
AID - 10.5144/0256-4947.2012.01.7.1500 [doi]
PST - aheadofprint
SO  - Ann Saudi Med. 2012 Jul 1;32(6):1-2. doi: 10.5144/0256-4947.2012.01.7.1500.