PMID- 22751037
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20220309
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 15
IP  - 8
DP  - 2012 Jul 1
TI  - Memory signals are temporally dissociated in and across human hippocampus and 
      perirhinal cortex.
PG  - 1167-73
LID - 10.1038/nn.3154 [doi]
AB  - In the endeavor to understand how our brains enable our multifaceted memories, 
      much controversy surrounds the contributions of the hippocampus and perirhinal 
      cortex (PrC). We recorded functional magnetic resonance imaging (fMRI) in healthy 
      controls and intracranial electroencephalography (EEG) in patients during a 
      recognition memory task. Although conventional fMRI analysis showed 
      indistinguishable roles of the hippocampus and PrC in familiarity-based item 
      recognition and recollection-based source retrieval, event-related fMRI and EEG 
      time courses revealed a clear temporal dissociation of memory signals in and 
      across these regions. An early source retrieval effect was followed by a late, 
      post-decision item novelty effect in hippocampus, whereas an early item novelty 
      effect was followed by a sustained source retrieval effect in PrC. Although 
      factors such as memory strength were not experimentally controlled, the temporal 
      pattern across regions suggests that a rapid item recognition signal in PrC 
      triggers a source retrieval process in the hippocampus, which in turn recruits 
      PrC representations and/or mechanisms, evidenced here by increased 
      hippocampal-PrC coupling during source recognition.
FAU - Staresina, Bernhard P
AU  - Staresina BP
AD  - Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK. 
      bernhard.staresina@mrc-cbu.cam.ac.uk
FAU - Fell, Juergen
AU  - Fell J
FAU - Do Lam, Anne T A
AU  - Do Lam AT
FAU - Axmacher, Nikolai
AU  - Axmacher N
FAU - Henson, Richard N
AU  - Henson RN
LA  - eng
GR  - 089049/WT_/Wellcome Trust/United Kingdom
GR  - MC_U105579226/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120701
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
SB  - IM
MH  - Adult
MH  - Electrodes, Implanted
MH  - Electroencephalography/instrumentation/*methods
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Hippocampus/*physiology/physiopathology/surgery
MH  - Humans
MH  - Magnetic Resonance Imaging/instrumentation/*methods
MH  - Mental Recall/*physiology
MH  - Neuropsychological Tests
MH  - Recognition, Psychology/*physiology
MH  - Signal Transduction/physiology
MH  - Temporal Lobe/*physiology/physiopathology/surgery
MH  - Time Factors
MH  - Young Adult
PMC - PMC3428860
MID - UKMS48754
OID - NLM: UKMS48754
EDAT- 2012/07/04 06:00
MHDA- 2012/10/26 06:00
PMCR- 2013/02/01
CRDT- 2012/07/04 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/05/29 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - nn.3154 [pii]
AID - 10.1038/nn.3154 [doi]
PST - epublish
SO  - Nat Neurosci. 2012 Jul 1;15(8):1167-73. doi: 10.1038/nn.3154.