PMID- 22752804
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20221207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 9
DP  - 2012 Sep
TI  - Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease 
      susceptibility.
PG  - 9023-30
LID - 10.1007/s11033-012-1773-y [doi]
AB  - Coronary artery disease (CAD) was the second leading cause of death during the 
      last 3 years in Taiwan. Smooth muscle cells, monocytes/macrophages, and 
      endothelial cells produce monocyte chemoattractant protein-1 (MCP-1) within 
      atherosclerotic plaques following binding to the chemokine receptor-2 (CCR-2). 
      Previous studies have well-documented the association between MCP-1 expression 
      and susceptibility to, or clinicopathological features, of CAD. This study 
      investigated the relationships between MCP-1-2518A/G and CCR-2-V64I genetic 
      polymorphisms and CAD in the Taiwanese population. A total of 608 subjects, 
      including 392 non-CAD controls and 216 patients with CAD, were recruited and 
      subjected to polymerase chain reaction-restriction fragment length polymorphism 
      (PCR-RFLP) to evaluate the effects of these two polymorphic variants on CAD. 
      Results indicated a significant association between MCP-1 -2548 gene polymorphism 
      and susceptibility to CAD. GG genotypes (OR = 1.629; 95 % CI = 1.003-2.644), or 
      individuals with at least one G allele (OR = 1.511; 95 % CI = 1.006-2.270), had a 
      higher risk of CAD as compared with AA genotypes. Results also revealed that 
      subjects with at least one A allele of the V64I CCR2 gene polymorphism had 
      significantly increased risk of CAD. G allele in MCP-1-2518 might contribute to 
      higher prevalence of atrial fibrillation in CAD patients (OR = 4.254; p < 0.05). 
      In conclusion, MCP-1-2518G and CCR-2 64I gene polymorphisms represent important 
      factors in determining susceptibility to CAD, and the contribution of MCP-1-2518G 
      could be through effects on atrial fibrillation in CAD patients.
FAU - Lin, Hsiu-Ling
AU  - Lin HL
AD  - Institute of Biochemistry and Biotechnology, Chung Shan Medical University, 
      Taichung, Taiwan.
FAU - Ueng, Kwo-Chang
AU  - Ueng KC
FAU - Hsieh, Yih-Shou
AU  - Hsieh YS
FAU - Chiang, Whei-Ling
AU  - Chiang WL
FAU - Yang, Shun-Fa
AU  - Yang SF
FAU - Chu, Shu-Chen
AU  - Chu SC
LA  - eng
PT  - Journal Article
DEP - 20120703
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Chemokine CCL2/*genetics
MH  - Coronary Artery Disease/*genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, CCR2/*genetics
MH  - Risk Factors
EDAT- 2012/07/04 06:00
MHDA- 2012/12/15 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/06/09 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 10.1007/s11033-012-1773-y [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Sep;39(9):9023-30. doi: 10.1007/s11033-012-1773-y. Epub 2012 
      Jul 3.