PMID- 22753132
OWN - NLM
STAT- MEDLINE
DCOM- 20130718
LR  - 20211021
IS  - 1439-0973 (Electronic)
IS  - 0300-8126 (Linking)
VI  - 41
IP  - 1
DP  - 2013 Feb
TI  - Toll-like receptor-4 expression in infants with pertussis infection.
PG  - 195-8
LID - 10.1007/s15010-012-0288-8 [doi]
AB  - PURPOSE: Our aim was to evaluate the expression of Toll-like receptor-4 (TLR-4) 
      and the level of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) in young 
      infants infected by Bordetella pertussis and B. parapertussis. METHODS: 
      Twenty-two infants under the age of 3.5 months with the clinical suspicion of 
      pertussis were enrolled in the study. Nasopharyngeal secretions were obtained for 
      laboratory testing, and blood samples were obtained for flow cytometry and 
      cytokine level analysis. RESULTS: Six infants had positive PCR results for 
      pertussis; the other 16 infants had infections attributable to another causal 
      agent and were used as the control group. The mean fluorescence index, used as a 
      measure of TLR-4 expression by monocytes, was significantly lower in infants with 
      pertussis than in the control group infants (34.32 +/- 18.58 vs. 63.14 +/- 28, 
      respectively; p = 0.041). The serum IFN-gamma level was also significantly lower in 
      infants with pertussis than in the control group patients (0.41 +/- 0.58 vs. 1.36 +/- 
      1.87, respectively; p = 0.04). No differences were found in the levels of IL-10. 
      CONCLUSIONS: Based on these results, we suggest that TL4 expression by monocytes 
      and serum INF-gamma levels are lower in infants with positive PCR results for 
      pertussis than in infants with a non-pertussis upper respiratory tract infection.
FAU - Vadasz, Z
AU  - Vadasz Z
AD  - Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, 47 Golomb 
      Street, P.O. Box 4940, 31048, Haifa, Israel.
FAU - Bamberger, E
AU  - Bamberger E
FAU - Ben-Tikva, K
AU  - Ben-Tikva K
FAU - Feterman, M
AU  - Feterman M
FAU - Srugo, I
AU  - Srugo I
FAU - Kessel, A
AU  - Kessel A
LA  - eng
PT  - Journal Article
DEP - 20120703
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Toll-Like Receptor 4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Bordetella parapertussis/genetics
MH  - Bordetella pertussis/genetics
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interferon-gamma/blood
MH  - Male
MH  - Monocytes/metabolism
MH  - Toll-Like Receptor 4/blood/*metabolism
MH  - Whooping Cough/blood/diagnosis/*metabolism
EDAT- 2012/07/04 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/01/02 00:00 [received]
PHST- 2012/06/15 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - 10.1007/s15010-012-0288-8 [doi]
PST - ppublish
SO  - Infection. 2013 Feb;41(1):195-8. doi: 10.1007/s15010-012-0288-8. Epub 2012 Jul 3.