PMID- 22754483
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 9
IP  - 5
DP  - 2012 May
TI  - The aryl hydrocarbon receptor pathway: a key component of the microRNA-mediated 
      AML signalisome.
PG  - 1939-53
LID - 10.3390/ijerph9051939 [doi]
AB  - Recent research has spotlighted the role of microRNAs (miRNAs) as critical 
      epigenetic regulators of hematopoietic stem cell differentiation and leukemia 
      development. Despite the recent advances in knowledge surrounding epigenetics and 
      leukemia, the mechanisms underlying miRNAs' influence on leukemia development 
      have yet to be clearly elucidated. Our aim was to identify high ranking 
      biological pathways altered at the gene expression level and under epigenetic 
      control. Specifically, we set out to test the hypothesis that miRNAs dysregulated 
      in acute myeloid leukemia (AML) converge on a common pathway that can influence 
      signaling related to hematopoiesis and leukemia development. We identified genes 
      altered in AML patients that are under common regulation of seven key miRNAs. By 
      mapping these genes to a global interaction network, we identified the "AML 
      Signalisome". The AML Signalisome comprises 53 AML-associated molecules, and is 
      enriched for proteins that play a role in the aryl hydrocarbon receptor (AhR) 
      pathway, a major regulator of hematopoiesis. Furthermore, we show biological 
      enrichment for hematopoiesis-related proteins within the AML Signalisome. These 
      findings provide important insight into miRNA-regulated pathways in leukemia, and 
      may help to prioritize targets for disease prevention and treatment.
FAU - Rager, Julia E
AU  - Rager JE
AD  - Department of Environmental Sciences and Engineering, Gillings School of Global 
      Public Health, The University of North Carolina, 135 Dauer Drive, CB 7431, UNC, 
      Chapel Hill, NC 27599, USA. jrager@live.unc.edu
FAU - Fry, Rebecca C
AU  - Fry RC
LA  - eng
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - P42 ES005948/ES/NIEHS NIH HHS/United States
GR  - R01 ES019315/ES/NIEHS NIH HHS/United States
GR  - ES019315/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120518
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (MicroRNAs)
RN  - 0 (Receptors, Aryl Hydrocarbon)
SB  - IM
MH  - Gene Expression Regulation, Leukemic
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - MicroRNAs/*genetics
MH  - Receptors, Aryl Hydrocarbon/*genetics
MH  - Signal Transduction
PMC - PMC3386597
OTO - NOTNLM
OT  - aryl hydrocarbon receptor
OT  - gene expression
OT  - leukemia
OT  - microRNA
OT  - systems biology
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
PMCR- 2012/05/01
CRDT- 2012/07/04 06:00
PHST- 2012/03/21 00:00 [received]
PHST- 2012/04/27 00:00 [revised]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - ijerph9051939 [pii]
AID - ijerph-09-01939 [pii]
AID - 10.3390/ijerph9051939 [doi]
PST - ppublish
SO  - Int J Environ Res Public Health. 2012 May;9(5):1939-53. doi: 
      10.3390/ijerph9051939. Epub 2012 May 18.